node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alkbh5 | Mettl14 | ENSRNOP00000034155 | ENSRNOP00000020574 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | 0.954 |
Alkbh5 | Mettl3 | ENSRNOP00000034155 | ENSRNOP00000017720 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | Methyltransferase-like 3, isoform CRA_b; Belongs to the MT-A70-like family. | 0.879 |
Alkbh5 | Prrc2a | ENSRNOP00000034155 | ENSRNOP00000075873 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.577 |
Alkbh5 | Ythdc1 | ENSRNOP00000034155 | ENSRNOP00000002736 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | YTH domain-containing protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and acts as a regulator of alternative splicing. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjac [...] | 0.882 |
Alkbh5 | Ythdc2 | ENSRNOP00000034155 | ENSRNOP00000056847 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | YTH domain-containing 2. | 0.882 |
Alkbh5 | Ythdf1 | ENSRNOP00000034155 | ENSRNOP00000037700 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | YTH N(6)-methyladenosine RNA-binding protein 1. | 0.942 |
Alkbh5 | Ythdf2 | ENSRNOP00000034155 | ENSRNOP00000014479 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | YTH N(6)-methyladenosine RNA-binding protein 2. | 0.896 |
Alkbh5 | Ythdf3 | ENSRNOP00000034155 | ENSRNOP00000060081 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | YTH N(6)-methyladenosine RNA-binding protein 3. | 0.866 |
Bag6 | Prrc2a | ENSRNOP00000057557 | ENSRNOP00000075873 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.634 |
Mettl14 | Alkbh5 | ENSRNOP00000020574 | ENSRNOP00000034155 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | 0.954 |
Mettl14 | Mettl3 | ENSRNOP00000020574 | ENSRNOP00000017720 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | Methyltransferase-like 3, isoform CRA_b; Belongs to the MT-A70-like family. | 0.999 |
Mettl14 | Prrc2a | ENSRNOP00000020574 | ENSRNOP00000075873 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.651 |
Mettl14 | Ythdc1 | ENSRNOP00000020574 | ENSRNOP00000002736 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | YTH domain-containing protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and acts as a regulator of alternative splicing. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjac [...] | 0.908 |
Mettl14 | Ythdc2 | ENSRNOP00000020574 | ENSRNOP00000056847 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | YTH domain-containing 2. | 0.891 |
Mettl14 | Ythdf1 | ENSRNOP00000020574 | ENSRNOP00000037700 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | YTH N(6)-methyladenosine RNA-binding protein 1. | 0.961 |
Mettl14 | Ythdf2 | ENSRNOP00000020574 | ENSRNOP00000014479 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | YTH N(6)-methyladenosine RNA-binding protein 2. | 0.945 |
Mettl14 | Ythdf3 | ENSRNOP00000020574 | ENSRNOP00000060081 | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | YTH N(6)-methyladenosine RNA-binding protein 3. | 0.919 |
Mettl3 | Alkbh5 | ENSRNOP00000017720 | ENSRNOP00000034155 | Methyltransferase-like 3, isoform CRA_b; Belongs to the MT-A70-like family. | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round sperma [...] | 0.879 |
Mettl3 | Mettl14 | ENSRNOP00000017720 | ENSRNOP00000020574 | Methyltransferase-like 3, isoform CRA_b; Belongs to the MT-A70-like family. | Similar to KIAA1627 protein (Predicted), isoform CRA_b; Belongs to the MT-A70-like family. | 0.999 |
Mettl3 | Prrc2a | ENSRNOP00000017720 | ENSRNOP00000075873 | Methyltransferase-like 3, isoform CRA_b; Belongs to the MT-A70-like family. | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing. | 0.580 |