STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Kctd7BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons. (289 aa)    
Predicted Functional Partners:
Cul3
Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the [...]
    
 0.687
Tbl2
Transducin (beta)-like 2.
      
 0.609
Asb1
Ankyrin repeat and SOCS box-containing protein 1 (Predicted), isoform CRA_a.
   
  
 0.581
Anapc13
Anaphase-promoting complex subunit 13.
      
 0.571
Asb13
Ankyrin repeat and SOCS box-containing 13 (Predicted), isoform CRA_b.
      
 0.571
Ppt1
Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Belongs to the palmitoyl-protein thioesterase family.
   
  
 0.562
Ube2m
Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.530
Cln6
CLN6, transmembrane ER protein.
      
 0.526
Fbxo41
F-box protein 41.
   
  
 0.515
Commd1
Copper metabolism domain-containing 1.
     
 0.513
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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