node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Esr1 | Greb1 | ENSRNOP00000026350 | ENSRNOP00000036412 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Growth-regulating estrogen receptor-binding 1. | 0.862 |
Esr1 | Pgr | ENSRNOP00000026350 | ENSRNOP00000032053 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.981 |
Esr1 | Tff1 | ENSRNOP00000026350 | ENSRNOP00000001538 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. | 0.517 |
Gkn1 | Gkn2 | ENSRNOP00000012218 | ENSRNOP00000063736 | Gastrokine 1. | Gastrokine-2. | 0.689 |
Gkn1 | Muc6 | ENSRNOP00000012218 | ENSRNOP00000072558 | Gastrokine 1. | Mucin 6, oligomeric mucus/gel-forming. | 0.606 |
Gkn1 | Tff1 | ENSRNOP00000012218 | ENSRNOP00000001538 | Gastrokine 1. | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. | 0.629 |
Gkn1 | Tff2 | ENSRNOP00000012218 | ENSRNOP00000001537 | Gastrokine 1. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.561 |
Gkn2 | Gkn1 | ENSRNOP00000063736 | ENSRNOP00000012218 | Gastrokine-2. | Gastrokine 1. | 0.689 |
Gkn2 | Tff1 | ENSRNOP00000063736 | ENSRNOP00000001538 | Gastrokine-2. | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. | 0.810 |
Gkn2 | Tff2 | ENSRNOP00000063736 | ENSRNOP00000001537 | Gastrokine-2. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. | 0.567 |
Greb1 | Esr1 | ENSRNOP00000036412 | ENSRNOP00000026350 | Growth-regulating estrogen receptor-binding 1. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.862 |
Greb1 | Pgr | ENSRNOP00000036412 | ENSRNOP00000032053 | Growth-regulating estrogen receptor-binding 1. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.708 |
Greb1 | Tff1 | ENSRNOP00000036412 | ENSRNOP00000001538 | Growth-regulating estrogen receptor-binding 1. | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. | 0.627 |
Muc2 | Muc5ac | ENSRNOP00000064975 | ENSRNOP00000072033 | Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (By similarity). | Uncharacterized protein. | 0.540 |
Muc2 | Muc5b | ENSRNOP00000064975 | ENSRNOP00000036806 | Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (By similarity). | Mucin 5B, oligomeric mucus/gel-forming. | 0.557 |
Muc2 | Muc6 | ENSRNOP00000064975 | ENSRNOP00000072558 | Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (By similarity). | Mucin 6, oligomeric mucus/gel-forming. | 0.624 |
Muc2 | Tff1 | ENSRNOP00000064975 | ENSRNOP00000001538 | Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (By similarity). | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. | 0.460 |
Muc5ac | Muc2 | ENSRNOP00000072033 | ENSRNOP00000064975 | Uncharacterized protein. | Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (By similarity). | 0.540 |
Muc5ac | Muc5b | ENSRNOP00000072033 | ENSRNOP00000036806 | Uncharacterized protein. | Mucin 5B, oligomeric mucus/gel-forming. | 0.515 |
Muc5ac | Muc6 | ENSRNOP00000072033 | ENSRNOP00000072558 | Uncharacterized protein. | Mucin 6, oligomeric mucus/gel-forming. | 0.681 |