node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ddx58 | Ifi44 | ENSRNOP00000057492 | ENSRNOP00000071211 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Interferon-induced protein 44, isoform CRA_a. | 0.947 |
Ddx58 | Ifit1 | ENSRNOP00000057492 | ENSRNOP00000025770 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Interferon-induced protein with tetratricopeptide repeats 1. | 0.876 |
Ddx58 | Ifit2 | ENSRNOP00000057492 | ENSRNOP00000051639 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Interferon-induced protein with tetratricopeptide repeats 2. | 0.884 |
Ddx58 | Irf7 | ENSRNOP00000057492 | ENSRNOP00000023504 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Interferon regulatory factor 7. | 0.900 |
Ddx58 | Isg15 | ENSRNOP00000057492 | ENSRNOP00000035405 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.995 |
Ddx58 | Oasl | ENSRNOP00000057492 | ENSRNOP00000001570 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L (By similarity). | 0.847 |
Ddx58 | Oasl2 | ENSRNOP00000057492 | ENSRNOP00000001600 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | 2'-5'-oligoadenylate synthase-like protein 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent p [...] | 0.904 |
Ddx58 | Rsad2 | ENSRNOP00000057492 | ENSRNOP00000010092 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.908 |
Ddx58 | Rtp4 | ENSRNOP00000057492 | ENSRNOP00000045711 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Receptor (chemosensory) transporter protein 4. | 0.771 |
Ddx58 | Usp18 | ENSRNOP00000057492 | ENSRNOP00000053020 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. | 0.913 |
Ifi44 | Ddx58 | ENSRNOP00000071211 | ENSRNOP00000057492 | Interferon-induced protein 44, isoform CRA_a. | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Predicted). | 0.947 |
Ifi44 | Ifit1 | ENSRNOP00000071211 | ENSRNOP00000025770 | Interferon-induced protein 44, isoform CRA_a. | Interferon-induced protein with tetratricopeptide repeats 1. | 0.974 |
Ifi44 | Ifit2 | ENSRNOP00000071211 | ENSRNOP00000051639 | Interferon-induced protein 44, isoform CRA_a. | Interferon-induced protein with tetratricopeptide repeats 2. | 0.868 |
Ifi44 | Irf7 | ENSRNOP00000071211 | ENSRNOP00000023504 | Interferon-induced protein 44, isoform CRA_a. | Interferon regulatory factor 7. | 0.882 |
Ifi44 | Isg15 | ENSRNOP00000071211 | ENSRNOP00000035405 | Interferon-induced protein 44, isoform CRA_a. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.944 |
Ifi44 | Oasl | ENSRNOP00000071211 | ENSRNOP00000001570 | Interferon-induced protein 44, isoform CRA_a. | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L (By similarity). | 0.857 |
Ifi44 | Oasl2 | ENSRNOP00000071211 | ENSRNOP00000001600 | Interferon-induced protein 44, isoform CRA_a. | 2'-5'-oligoadenylate synthase-like protein 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent p [...] | 0.939 |
Ifi44 | Rsad2 | ENSRNOP00000071211 | ENSRNOP00000010092 | Interferon-induced protein 44, isoform CRA_a. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.970 |
Ifi44 | Rtp4 | ENSRNOP00000071211 | ENSRNOP00000045711 | Interferon-induced protein 44, isoform CRA_a. | Receptor (chemosensory) transporter protein 4. | 0.921 |
Ifi44 | Usp18 | ENSRNOP00000071211 | ENSRNOP00000053020 | Interferon-induced protein 44, isoform CRA_a. | Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family. | 0.939 |