node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atxn2 | Atxn2l | ENSRNOP00000001691 | ENSRNOP00000070616 | Ataxin 2. | Ataxin 2-like. | 0.919 |
Atxn2 | Atxn3 | ENSRNOP00000001691 | ENSRNOP00000007505 | Ataxin 2. | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | 0.975 |
Atxn2 | Ddx6 | ENSRNOP00000001691 | ENSRNOP00000073900 | Ataxin 2. | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | 0.913 |
Atxn2 | Itpr1 | ENSRNOP00000001691 | ENSRNOP00000043615 | Ataxin 2. | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | 0.987 |
Atxn2 | Itpr2 | ENSRNOP00000001691 | ENSRNOP00000047905 | Ataxin 2. | Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). | 0.908 |
Atxn2 | Itpr3 | ENSRNOP00000001691 | ENSRNOP00000075066 | Ataxin 2. | Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. | 0.906 |
Atxn2 | Lsm12 | ENSRNOP00000001691 | ENSRNOP00000028368 | Ataxin 2. | LSM12 homolog. | 0.916 |
Atxn2 | Pabpc1 | ENSRNOP00000001691 | ENSRNOP00000012775 | Ataxin 2. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.911 |
Atxn2 | Rbfox1 | ENSRNOP00000001691 | ENSRNOP00000059781 | Ataxin 2. | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events. | 0.967 |
Atxn2 | Tardbp | ENSRNOP00000001691 | ENSRNOP00000041889 | Ataxin 2. | RCG31562, isoform CRA_c. | 0.951 |
Atxn2l | Atxn2 | ENSRNOP00000070616 | ENSRNOP00000001691 | Ataxin 2-like. | Ataxin 2. | 0.919 |
Atxn2l | Atxn3 | ENSRNOP00000070616 | ENSRNOP00000007505 | Ataxin 2-like. | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | 0.910 |
Atxn2l | Ddx6 | ENSRNOP00000070616 | ENSRNOP00000073900 | Ataxin 2-like. | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | 0.829 |
Atxn2l | Itpr1 | ENSRNOP00000070616 | ENSRNOP00000043615 | Ataxin 2-like. | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | 0.900 |
Atxn2l | Itpr2 | ENSRNOP00000070616 | ENSRNOP00000047905 | Ataxin 2-like. | Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). | 0.900 |
Atxn2l | Itpr3 | ENSRNOP00000070616 | ENSRNOP00000075066 | Ataxin 2-like. | Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. | 0.900 |
Atxn2l | Lsm12 | ENSRNOP00000070616 | ENSRNOP00000028368 | Ataxin 2-like. | LSM12 homolog. | 0.887 |
Atxn2l | Pabpc1 | ENSRNOP00000070616 | ENSRNOP00000012775 | Ataxin 2-like. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.773 |
Atxn3 | Atxn2 | ENSRNOP00000007505 | ENSRNOP00000001691 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | Ataxin 2. | 0.975 |
Atxn3 | Atxn2l | ENSRNOP00000007505 | ENSRNOP00000070616 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | Ataxin 2-like. | 0.910 |