node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actg1 | Actg1-2 | ENSRNOP00000051859 | ENSRNOP00000072273 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Actin, gamma 1 propeptide-like. | 0.722 |
Actg1 | Arpc2 | ENSRNOP00000051859 | ENSRNOP00000019265 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promot [...] | 0.950 |
Actg1 | Dusp22 | ENSRNOP00000051859 | ENSRNOP00000071916 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Dual specificity phosphatase 22 (Predicted), isoform CRA_a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.728 |
Actg1 | Map3k1 | ENSRNOP00000051859 | ENSRNOP00000017968 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | 0.751 |
Actg1 | Myo18b | ENSRNOP00000051859 | ENSRNOP00000065213 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.807 |
Actg1 | Myo1c | ENSRNOP00000051859 | ENSRNOP00000028929 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Unconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in st [...] | 0.928 |
Actg1 | Myo3a | ENSRNOP00000051859 | ENSRNOP00000025053 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.801 |
Actg1 | Pdlim4 | ENSRNOP00000051859 | ENSRNOP00000064261 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (By similarity). Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] | 0.757 |
Actg1 | Rac3 | ENSRNOP00000051859 | ENSRNOP00000064762 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Rac family small GTPase 3. | 0.757 |
Actg1 | Specc1l | ENSRNOP00000051859 | ENSRNOP00000001764 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity). | 0.737 |
Actg1-2 | Actg1 | ENSRNOP00000072273 | ENSRNOP00000051859 | Actin, gamma 1 propeptide-like. | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. | 0.722 |
Actg1-2 | Arpc2 | ENSRNOP00000072273 | ENSRNOP00000019265 | Actin, gamma 1 propeptide-like. | Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promot [...] | 0.838 |
Actg1-2 | Dusp22 | ENSRNOP00000072273 | ENSRNOP00000071916 | Actin, gamma 1 propeptide-like. | Dual specificity phosphatase 22 (Predicted), isoform CRA_a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.728 |
Actg1-2 | Map3k1 | ENSRNOP00000072273 | ENSRNOP00000017968 | Actin, gamma 1 propeptide-like. | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | 0.751 |
Actg1-2 | Myo18b | ENSRNOP00000072273 | ENSRNOP00000065213 | Actin, gamma 1 propeptide-like. | Myosin XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.795 |
Actg1-2 | Myo1c | ENSRNOP00000072273 | ENSRNOP00000028929 | Actin, gamma 1 propeptide-like. | Unconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in st [...] | 0.765 |
Actg1-2 | Myo3a | ENSRNOP00000072273 | ENSRNOP00000025053 | Actin, gamma 1 propeptide-like. | Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.810 |
Actg1-2 | Pdlim4 | ENSRNOP00000072273 | ENSRNOP00000064261 | Actin, gamma 1 propeptide-like. | PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (By similarity). Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] | 0.756 |
Actg1-2 | Rac3 | ENSRNOP00000072273 | ENSRNOP00000064762 | Actin, gamma 1 propeptide-like. | Rac family small GTPase 3. | 0.757 |
Actg1-2 | Specc1l | ENSRNOP00000072273 | ENSRNOP00000001764 | Actin, gamma 1 propeptide-like. | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity). | 0.737 |