node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Itpr1 | Nfat5 | ENSRNOP00000043615 | ENSRNOP00000017005 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | 0.657 |
Itpr1 | Orai2 | ENSRNOP00000043615 | ENSRNOP00000001938 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Calcium release-activated calcium modulator 2 protein. | 0.700 |
Itpr1 | Orai3 | ENSRNOP00000043615 | ENSRNOP00000025732 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Protein orai-3; Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. | 0.658 |
Itpr1 | Stim1 | ENSRNOP00000043615 | ENSRNOP00000027685 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation (By similarity). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (By similarity). | 0.942 |
Itpr1 | Stim2 | ENSRNOP00000043615 | ENSRNOP00000004006 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Stromal interaction molecule 2. | 0.770 |
Itpr1 | Trpc1 | ENSRNOP00000043615 | ENSRNOP00000074229 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. | 0.893 |
Itpr1 | Trpc3 | ENSRNOP00000043615 | ENSRNOP00000075444 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC [...] | 0.935 |
Itpr1 | Trpc4 | ENSRNOP00000043615 | ENSRNOP00000042886 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Short transient receptor potential channel 4; Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium- selective (By similarity). May also be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. | 0.639 |
Itpr1 | Trpc5 | ENSRNOP00000043615 | ENSRNOP00000071700 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Transient receptor potential cation channel, subfamily C, member 5; Belongs to the transient receptor (TC 1.A.4) family. | 0.599 |
Itpr1 | Trpc6 | ENSRNOP00000043615 | ENSRNOP00000008905 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | Transient receptor potential cation channel, subfamily C, member 6, isoform CRA_b; Belongs to the transient receptor (TC 1.A.4) family. | 0.699 |
Nfat5 | Itpr1 | ENSRNOP00000017005 | ENSRNOP00000043615 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Belongs to the InsP3 receptor family. | 0.657 |
Nfat5 | Orai2 | ENSRNOP00000017005 | ENSRNOP00000001938 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Calcium release-activated calcium modulator 2 protein. | 0.667 |
Nfat5 | Orai3 | ENSRNOP00000017005 | ENSRNOP00000025732 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Protein orai-3; Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. | 0.686 |
Nfat5 | Stim1 | ENSRNOP00000017005 | ENSRNOP00000027685 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation (By similarity). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (By similarity). | 0.794 |
Nfat5 | Stim2 | ENSRNOP00000017005 | ENSRNOP00000004006 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Stromal interaction molecule 2. | 0.724 |
Nfat5 | Trpc1 | ENSRNOP00000017005 | ENSRNOP00000074229 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. | 0.635 |
Nfat5 | Trpc3 | ENSRNOP00000017005 | ENSRNOP00000075444 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC [...] | 0.640 |
Nfat5 | Trpc4 | ENSRNOP00000017005 | ENSRNOP00000042886 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Short transient receptor potential channel 4; Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium- selective (By similarity). May also be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. | 0.507 |
Nfat5 | Trpc5 | ENSRNOP00000017005 | ENSRNOP00000071700 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Transient receptor potential cation channel, subfamily C, member 5; Belongs to the transient receptor (TC 1.A.4) family. | 0.506 |
Nfat5 | Trpc6 | ENSRNOP00000017005 | ENSRNOP00000008905 | Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes. | Transient receptor potential cation channel, subfamily C, member 6, isoform CRA_b; Belongs to the transient receptor (TC 1.A.4) family. | 0.698 |