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Fzd9 protein (Rattus norvegicus) - STRING interaction network
"Fzd9" - Frizzled-9 in Rattus norvegicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Fzd9Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell c [...] (592 aa)    
Predicted Functional Partners:
Wnt11
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (354 aa)
     
  0.924
Wnt1
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (370 aa)
       
  0.922
Lrp5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes (1600 aa)
     
  0.920
Lrp6
Low density lipoprotein receptor-related protein 6 (1234 aa)
       
  0.905
Wnt2
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (360 aa)
     
  0.898
Wnt3a
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (352 aa)
     
  0.897
Wnt5a
Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferatio [...] (380 aa)
     
  0.883
Wnt16
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (364 aa)
     
  0.874
Wnt4
Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors. May be an intracellular signaling molecule involved in segmentation of the forebrain. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family (351 aa)
     
  0.865
Wnt7a
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (349 aa)
     
  0.859
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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