node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akap10 | Rab4b | ENSRNOP00000003871 | ENSRNOP00000002052 | A-kinase-anchoring protein 10. | Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.688 |
Arf6 | Eea1 | ENSRNOP00000006355 | ENSRNOP00000071305 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | Early endosome antigen 1. | 0.748 |
Arf6 | Itsn2 | ENSRNOP00000006355 | ENSRNOP00000065329 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | Intersectin 2. | 0.790 |
Arf6 | Rab4b | ENSRNOP00000006355 | ENSRNOP00000002052 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.730 |
Arf6 | Rab6a | ENSRNOP00000006355 | ENSRNOP00000025104 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Belongs to the small GTPase superfamily. Rab family. | 0.488 |
Arf6 | Rbsn | ENSRNOP00000006355 | ENSRNOP00000015602 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | Zinc finger, FYVE domain containing 20 (Predicted). | 0.511 |
Eea1 | Arf6 | ENSRNOP00000071305 | ENSRNOP00000006355 | Early endosome antigen 1. | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | 0.748 |
Eea1 | Gripap1 | ENSRNOP00000071305 | ENSRNOP00000012646 | Early endosome antigen 1. | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. | 0.472 |
Eea1 | Rab3a | ENSRNOP00000071305 | ENSRNOP00000026392 | Early endosome antigen 1. | Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through in [...] | 0.440 |
Eea1 | Rab4b | ENSRNOP00000071305 | ENSRNOP00000002052 | Early endosome antigen 1. | Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.661 |
Eea1 | Rab6a | ENSRNOP00000071305 | ENSRNOP00000025104 | Early endosome antigen 1. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Belongs to the small GTPase superfamily. Rab family. | 0.512 |
Eea1 | Rabep1 | ENSRNOP00000071305 | ENSRNOP00000050017 | Early endosome antigen 1. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. | 0.940 |
Eea1 | Rbsn | ENSRNOP00000071305 | ENSRNOP00000015602 | Early endosome antigen 1. | Zinc finger, FYVE domain containing 20 (Predicted). | 0.408 |
Gripap1 | Eea1 | ENSRNOP00000012646 | ENSRNOP00000071305 | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. | Early endosome antigen 1. | 0.472 |
Gripap1 | Rab4b | ENSRNOP00000012646 | ENSRNOP00000002052 | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. | Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.692 |
Gripap1 | Rabep1 | ENSRNOP00000012646 | ENSRNOP00000050017 | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. | 0.400 |
Gripap1 | Rbsn | ENSRNOP00000012646 | ENSRNOP00000015602 | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. | Zinc finger, FYVE domain containing 20 (Predicted). | 0.480 |
Itsn2 | Arf6 | ENSRNOP00000065329 | ENSRNOP00000006355 | Intersectin 2. | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes ; Belon [...] | 0.790 |
Itsn2 | Rab4b | ENSRNOP00000065329 | ENSRNOP00000002052 | Intersectin 2. | Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.666 |
Itsn2 | Rabep1 | ENSRNOP00000065329 | ENSRNOP00000050017 | Intersectin 2. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. | 0.461 |