Riox2 protein (Rattus norvegicus) - STRING interaction network

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Riox2

Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily. (463 aa)

Predicted Functional Partners:

Rpl8

0.757

LOC100360117

0.722

LOC100910370

0.722

Rpl27a

0.650

Prss45

0.640

Jmjd4

0.633

Dip2b

0.602

Ogfod1

0.596

Tyw5

0.572

Helz2

0.571

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dip2b	Helz2	ENSRNOP00000070489	ENSRNOP00000017787	Disco-interacting protein 2 homolog B.	Helicase with zinc finger 2.	0.589
Dip2b	Riox2	ENSRNOP00000070489	ENSRNOP00000002285	Disco-interacting protein 2 homolog B.	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.602
Helz2	Dip2b	ENSRNOP00000017787	ENSRNOP00000070489	Helicase with zinc finger 2.	Disco-interacting protein 2 homolog B.	0.589
Helz2	Riox2	ENSRNOP00000017787	ENSRNOP00000002285	Helicase with zinc finger 2.	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.571
Jmjd4	Ogfod1	ENSRNOP00000037005	ENSRNOP00000026118	Jumonji domain containing 4 (Predicted).	2-oxoglutarate and iron-dependent oxygenase domain-containing 1.	0.556
Jmjd4	Riox2	ENSRNOP00000037005	ENSRNOP00000002285	Jumonji domain containing 4 (Predicted).	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.633
Jmjd4	Tyw5	ENSRNOP00000037005	ENSRNOP00000013502	Jumonji domain containing 4 (Predicted).	tRNA-yW synthesizing protein 5.	0.559
LOC100360117	LOC100910370	ENSRNOP00000046553	ENSRNOP00000067080	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	60S ribosomal protein L8.	0.942
LOC100360117	Riox2	ENSRNOP00000046553	ENSRNOP00000002285	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.722
LOC100360117	Rpl27a	ENSRNOP00000046553	ENSRNOP00000019247	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	60S ribosomal protein L27a.	0.994
LOC100360117	Rpl8	ENSRNOP00000046553	ENSRNOP00000064566	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	Ribosomal protein L8.	0.942
LOC100910370	LOC100360117	ENSRNOP00000067080	ENSRNOP00000046553	60S ribosomal protein L8.	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	0.942
LOC100910370	Riox2	ENSRNOP00000067080	ENSRNOP00000002285	60S ribosomal protein L8.	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.722
LOC100910370	Rpl27a	ENSRNOP00000067080	ENSRNOP00000019247	60S ribosomal protein L8.	60S ribosomal protein L27a.	0.968
LOC100910370	Rpl8	ENSRNOP00000067080	ENSRNOP00000064566	60S ribosomal protein L8.	Ribosomal protein L8.	0.967
Ogfod1	Jmjd4	ENSRNOP00000026118	ENSRNOP00000037005	2-oxoglutarate and iron-dependent oxygenase domain-containing 1.	Jumonji domain containing 4 (Predicted).	0.556
Ogfod1	Riox2	ENSRNOP00000026118	ENSRNOP00000002285	2-oxoglutarate and iron-dependent oxygenase domain-containing 1.	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.596
Ogfod1	Tyw5	ENSRNOP00000026118	ENSRNOP00000013502	2-oxoglutarate and iron-dependent oxygenase domain-containing 1.	tRNA-yW synthesizing protein 5.	0.538
Prss45	Riox2	ENSRNOP00000040152	ENSRNOP00000002285	Inactive serine protease 45.	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	0.640
Riox2	Dip2b	ENSRNOP00000002285	ENSRNOP00000070489	Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily.	Disco-interacting protein 2 homolog B.	0.602

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