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Bdh1 protein (Rattus norvegicus) - STRING interaction network
"Bdh1" - D-beta-hydroxybutyrate dehydrogenase, mitochondrial in Rattus norvegicus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Bdh1D-beta-hydroxybutyrate dehydrogenase, mitochondrial; 3-hydroxybutyrate dehydrogenase, type 1 (344 aa)    
Predicted Functional Partners:
Oxct1
Succinyl-CoA-3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) (520 aa)
     
 
  0.973
Hmgcl
Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity); Belongs to the HMG-CoA lyase family (325 aa)
     
 
  0.972
Bdh2
3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) (255 aa)
     
 
  0.953
Aacs
Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family (672 aa)
     
 
  0.940
Hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues (343 aa)
         
  0.912
Acat1
Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism; Belongs to the thiolase family (424 aa)
     
   
  0.750
ENSRNOG00000045720
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers (395 aa)
       
 
  0.710
Hmgcs2
Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (508 aa)
     
   
  0.653
Cs
Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family (466 aa)
     
   
  0.639
B3gat2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Substrates include asialo-orosomucoid (ASOR), paragloboside (lacto-N- neotetraosylceramide), Gal-beta-1,4-GlcNAc-beta-1,3-Gal-beta-1,4- Glc-pyridylamine and Gal-beta-1,3-GlcNAc-beta-1,3-Gal-beta-1,4- Glc-pyridylamine (324 aa)
           
  0.577
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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