node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cbs | Heatr6 | ENSRNOP00000039968 | ENSRNOP00000003492 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | HEAT repeat-containing protein 6. | 0.572 |
Cbs | Stat3 | ENSRNOP00000039968 | ENSRNOP00000026760 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.431 |
Heatr4 | Heatr6 | ENSRNOP00000054933 | ENSRNOP00000003492 | HEAT repeat-containing 4. | HEAT repeat-containing protein 6. | 0.547 |
Heatr6 | Cbs | ENSRNOP00000003492 | ENSRNOP00000039968 | HEAT repeat-containing protein 6. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.572 |
Heatr6 | Heatr4 | ENSRNOP00000003492 | ENSRNOP00000054933 | HEAT repeat-containing protein 6. | HEAT repeat-containing 4. | 0.547 |
Heatr6 | Ints4 | ENSRNOP00000003492 | ENSRNOP00000016770 | HEAT repeat-containing protein 6. | Integrator complex subunit 4. | 0.512 |
Heatr6 | Ncoa3 | ENSRNOP00000003492 | ENSRNOP00000007768 | HEAT repeat-containing protein 6. | Nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interac [...] | 0.481 |
Heatr6 | Plekha8 | ENSRNOP00000003492 | ENSRNOP00000013528 | HEAT repeat-containing protein 6. | Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...] | 0.668 |
Heatr6 | Relch | ENSRNOP00000003492 | ENSRNOP00000020892 | HEAT repeat-containing protein 6. | RAB11-binding and LisH domain, coiled-coil and HEAT repeat-containing. | 0.518 |
Heatr6 | Rgn | ENSRNOP00000003492 | ENSRNOP00000010984 | HEAT repeat-containing protein 6. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities; Belongs to the SMP-30/CGR1 family. | 0.691 |
Heatr6 | Stat3 | ENSRNOP00000003492 | ENSRNOP00000026760 | HEAT repeat-containing protein 6. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.543 |
Heatr6 | Stk36 | ENSRNOP00000003492 | ENSRNOP00000022839 | HEAT repeat-containing protein 6. | Serine/threonine kinase 36. | 0.468 |
Heatr6 | Wap | ENSRNOP00000003492 | ENSRNOP00000073381 | HEAT repeat-containing protein 6. | Whey acidic protein; Could be a protease inhibitor. | 0.603 |
Ints4 | Heatr6 | ENSRNOP00000016770 | ENSRNOP00000003492 | Integrator complex subunit 4. | HEAT repeat-containing protein 6. | 0.512 |
Ints4 | Relch | ENSRNOP00000016770 | ENSRNOP00000020892 | Integrator complex subunit 4. | RAB11-binding and LisH domain, coiled-coil and HEAT repeat-containing. | 0.618 |
Ncoa3 | Heatr6 | ENSRNOP00000007768 | ENSRNOP00000003492 | Nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interac [...] | HEAT repeat-containing protein 6. | 0.481 |
Plekha8 | Heatr6 | ENSRNOP00000013528 | ENSRNOP00000003492 | Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...] | HEAT repeat-containing protein 6. | 0.668 |
Relch | Heatr6 | ENSRNOP00000020892 | ENSRNOP00000003492 | RAB11-binding and LisH domain, coiled-coil and HEAT repeat-containing. | HEAT repeat-containing protein 6. | 0.518 |
Relch | Ints4 | ENSRNOP00000020892 | ENSRNOP00000016770 | RAB11-binding and LisH domain, coiled-coil and HEAT repeat-containing. | Integrator complex subunit 4. | 0.618 |
Relch | Stk36 | ENSRNOP00000020892 | ENSRNOP00000022839 | RAB11-binding and LisH domain, coiled-coil and HEAT repeat-containing. | Serine/threonine kinase 36. | 0.457 |