node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ambra1 | Atg101 | ENSRNOP00000039742 | ENSRNOP00000010195 | Autophagy and beclin 1 regulator 1. | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | 0.868 |
Ambra1 | Atg13 | ENSRNOP00000039742 | ENSRNOP00000022841 | Autophagy and beclin 1 regulator 1. | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | 0.910 |
Ambra1 | Atg14 | ENSRNOP00000039742 | ENSRNOP00000016274 | Autophagy and beclin 1 regulator 1. | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | 0.999 |
Ambra1 | Becn1 | ENSRNOP00000039742 | ENSRNOP00000071966 | Autophagy and beclin 1 regulator 1. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.999 |
Ambra1 | Mtor | ENSRNOP00000039742 | ENSRNOP00000014167 | Autophagy and beclin 1 regulator 1. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.643 |
Ambra1 | Pik3c3 | ENSRNOP00000039742 | ENSRNOP00000060791 | Autophagy and beclin 1 regulator 1. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | 0.999 |
Ambra1 | Pik3r4 | ENSRNOP00000039742 | ENSRNOP00000018654 | Autophagy and beclin 1 regulator 1. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.998 |
Ambra1 | Rb1cc1 | ENSRNOP00000039742 | ENSRNOP00000060201 | Autophagy and beclin 1 regulator 1. | RB1-inducible coiled-coil 1 (Predicted). | 0.858 |
Ambra1 | Ulk2 | ENSRNOP00000039742 | ENSRNOP00000003792 | Autophagy and beclin 1 regulator 1. | Unc-51-like autophagy-activating kinase 2. | 0.975 |
Atg101 | Ambra1 | ENSRNOP00000010195 | ENSRNOP00000039742 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Autophagy and beclin 1 regulator 1. | 0.868 |
Atg101 | Atg13 | ENSRNOP00000010195 | ENSRNOP00000022841 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | 0.999 |
Atg101 | Atg14 | ENSRNOP00000010195 | ENSRNOP00000016274 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | 0.973 |
Atg101 | Atg2a | ENSRNOP00000010195 | ENSRNOP00000073173 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Autophagy-related 2A. | 0.732 |
Atg101 | Becn1 | ENSRNOP00000010195 | ENSRNOP00000071966 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.945 |
Atg101 | Mtor | ENSRNOP00000010195 | ENSRNOP00000014167 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.973 |
Atg101 | Pik3c3 | ENSRNOP00000010195 | ENSRNOP00000060791 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | 0.964 |
Atg101 | Pik3r4 | ENSRNOP00000010195 | ENSRNOP00000018654 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.933 |
Atg101 | Rb1cc1 | ENSRNOP00000010195 | ENSRNOP00000060201 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | RB1-inducible coiled-coil 1 (Predicted). | 0.999 |
Atg101 | Ulk2 | ENSRNOP00000010195 | ENSRNOP00000003792 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. | Unc-51-like autophagy-activating kinase 2. | 0.999 |
Atg13 | Ambra1 | ENSRNOP00000022841 | ENSRNOP00000039742 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Autophagy and beclin 1 regulator 1. | 0.910 |