node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akap4 | Cabyr | ENSRNOP00000003939 | ENSRNOP00000065843 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Calcium-binding tyrosine phosphorylation-regulated. | 0.696 |
Akap4 | Crisp2 | ENSRNOP00000003939 | ENSRNOP00000017996 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Cysteine-rich secretory protein 2; Belongs to the CRISP family. | 0.651 |
Akap4 | Fsip2 | ENSRNOP00000003939 | ENSRNOP00000068297 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Fibrous sheath-interacting protein 2. | 0.777 |
Akap4 | Gapdhs | ENSRNOP00000003939 | ENSRNOP00000059802 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). | 0.664 |
Akap4 | Odf1 | ENSRNOP00000003939 | ENSRNOP00000008700 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.718 |
Akap4 | Prkaca | ENSRNOP00000003939 | ENSRNOP00000044732 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.691 |
Akap4 | Prkacb | ENSRNOP00000003939 | ENSRNOP00000062228 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.687 |
Akap4 | Ropn1 | ENSRNOP00000003939 | ENSRNOP00000002975 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.747 |
Akap4 | Spam1 | ENSRNOP00000003939 | ENSRNOP00000009537 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity). | 0.694 |
Akap4 | Spata3 | ENSRNOP00000003939 | ENSRNOP00000023581 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | Spermatogenesis associated 3 (Predicted). | 0.711 |
Cabyr | Akap4 | ENSRNOP00000065843 | ENSRNOP00000003939 | Calcium-binding tyrosine phosphorylation-regulated. | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | 0.696 |
Cabyr | Fsip2 | ENSRNOP00000065843 | ENSRNOP00000068297 | Calcium-binding tyrosine phosphorylation-regulated. | Fibrous sheath-interacting protein 2. | 0.632 |
Cabyr | Odf1 | ENSRNOP00000065843 | ENSRNOP00000008700 | Calcium-binding tyrosine phosphorylation-regulated. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.598 |
Cabyr | Ropn1 | ENSRNOP00000065843 | ENSRNOP00000002975 | Calcium-binding tyrosine phosphorylation-regulated. | Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.765 |
Crisp2 | Akap4 | ENSRNOP00000017996 | ENSRNOP00000003939 | Cysteine-rich secretory protein 2; Belongs to the CRISP family. | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | 0.651 |
Crisp2 | Odf1 | ENSRNOP00000017996 | ENSRNOP00000008700 | Cysteine-rich secretory protein 2; Belongs to the CRISP family. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.539 |
Crisp2 | Spam1 | ENSRNOP00000017996 | ENSRNOP00000009537 | Cysteine-rich secretory protein 2; Belongs to the CRISP family. | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity). | 0.706 |
Fsip2 | Akap4 | ENSRNOP00000068297 | ENSRNOP00000003939 | Fibrous sheath-interacting protein 2. | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity). | 0.777 |
Fsip2 | Cabyr | ENSRNOP00000068297 | ENSRNOP00000065843 | Fibrous sheath-interacting protein 2. | Calcium-binding tyrosine phosphorylation-regulated. | 0.632 |
Fsip2 | Ropn1 | ENSRNOP00000068297 | ENSRNOP00000002975 | Fibrous sheath-interacting protein 2. | Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.613 |