node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akt1s1 | Deptor | ENSRNOP00000027478 | ENSRNOP00000005722 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | DEP domain-containing MTOR-interacting protein. | 0.999 |
Akt1s1 | Eif4b | ENSRNOP00000027478 | ENSRNOP00000014033 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Eukaryotic translation initiation factor 4B. | 0.592 |
Akt1s1 | Irs1 | ENSRNOP00000027478 | ENSRNOP00000019579 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. | 0.601 |
Akt1s1 | LOC100911372 | ENSRNOP00000027478 | ENSRNOP00000010383 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | 40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. | 0.582 |
Akt1s1 | Mlst8 | ENSRNOP00000027478 | ENSRNOP00000014269 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
Akt1s1 | Mtor | ENSRNOP00000027478 | ENSRNOP00000014167 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.999 |
Akt1s1 | Pdpk1 | ENSRNOP00000027478 | ENSRNOP00000061683 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central rol [...] | 0.474 |
Akt1s1 | Rps6kb1 | ENSRNOP00000027478 | ENSRNOP00000005226 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] | 0.985 |
Akt1s1 | Rptor | ENSRNOP00000027478 | ENSRNOP00000005337 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Regulatory-associated protein of MTOR, complex 1. | 0.999 |
Deptor | Akt1s1 | ENSRNOP00000005722 | ENSRNOP00000027478 | DEP domain-containing MTOR-interacting protein. | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | 0.999 |
Deptor | Eif4b | ENSRNOP00000005722 | ENSRNOP00000014033 | DEP domain-containing MTOR-interacting protein. | Eukaryotic translation initiation factor 4B. | 0.519 |
Deptor | Irs1 | ENSRNOP00000005722 | ENSRNOP00000019579 | DEP domain-containing MTOR-interacting protein. | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. | 0.489 |
Deptor | Mlst8 | ENSRNOP00000005722 | ENSRNOP00000014269 | DEP domain-containing MTOR-interacting protein. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
Deptor | Mtor | ENSRNOP00000005722 | ENSRNOP00000014167 | DEP domain-containing MTOR-interacting protein. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.999 |
Deptor | Rps6kb1 | ENSRNOP00000005722 | ENSRNOP00000005226 | DEP domain-containing MTOR-interacting protein. | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] | 0.974 |
Deptor | Rptor | ENSRNOP00000005722 | ENSRNOP00000005337 | DEP domain-containing MTOR-interacting protein. | Regulatory-associated protein of MTOR, complex 1. | 0.999 |
Eif4b | Akt1s1 | ENSRNOP00000014033 | ENSRNOP00000027478 | Eukaryotic translation initiation factor 4B. | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | 0.592 |
Eif4b | Deptor | ENSRNOP00000014033 | ENSRNOP00000005722 | Eukaryotic translation initiation factor 4B. | DEP domain-containing MTOR-interacting protein. | 0.519 |
Eif4b | LOC100911372 | ENSRNOP00000014033 | ENSRNOP00000010383 | Eukaryotic translation initiation factor 4B. | 40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. | 0.964 |
Eif4b | Mlst8 | ENSRNOP00000014033 | ENSRNOP00000014269 | Eukaryotic translation initiation factor 4B. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.552 |