node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmi1 | Ezh2 | ENSRNOP00000059998 | ENSRNOP00000008149 | BMI1 proto-oncogene, polycomb ring finger. | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | 0.983 |
Bmi1 | Hdac1 | ENSRNOP00000059998 | ENSRNOP00000012854 | BMI1 proto-oncogene, polycomb ring finger. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.488 |
Bmi1 | Hdac2 | ENSRNOP00000059998 | ENSRNOP00000000742 | BMI1 proto-oncogene, polycomb ring finger. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.873 |
Bmi1 | Ring1 | ENSRNOP00000059998 | ENSRNOP00000000543 | BMI1 proto-oncogene, polycomb ring finger. | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] | 0.999 |
Bmi1 | Rybp | ENSRNOP00000059998 | ENSRNOP00000007185 | BMI1 proto-oncogene, polycomb ring finger. | RING1 and YY1-binding protein. | 0.972 |
Bmi1 | Sirt1 | ENSRNOP00000059998 | ENSRNOP00000070943 | BMI1 proto-oncogene, polycomb ring finger. | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...] | 0.538 |
Bmi1 | Suz12 | ENSRNOP00000059998 | ENSRNOP00000072250 | BMI1 proto-oncogene, polycomb ring finger. | SUZ12 polycomb repressive complex 2 subunit. | 0.976 |
Bmi1 | Yy1 | ENSRNOP00000059998 | ENSRNOP00000005743 | BMI1 proto-oncogene, polycomb ring finger. | Transcription factor YY1. | 0.941 |
Ctcf | Ezh2 | ENSRNOP00000023851 | ENSRNOP00000008149 | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | 0.780 |
Ctcf | Hdac1 | ENSRNOP00000023851 | ENSRNOP00000012854 | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.509 |
Ctcf | Hdac2 | ENSRNOP00000023851 | ENSRNOP00000000742 | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.442 |
Ctcf | Suz12 | ENSRNOP00000023851 | ENSRNOP00000072250 | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] | SUZ12 polycomb repressive complex 2 subunit. | 0.906 |
Ctcf | Yy1 | ENSRNOP00000023851 | ENSRNOP00000005743 | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] | Transcription factor YY1. | 0.944 |
Ezh2 | Bmi1 | ENSRNOP00000008149 | ENSRNOP00000059998 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | BMI1 proto-oncogene, polycomb ring finger. | 0.983 |
Ezh2 | Ctcf | ENSRNOP00000008149 | ENSRNOP00000023851 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] | 0.780 |
Ezh2 | Hdac1 | ENSRNOP00000008149 | ENSRNOP00000012854 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.995 |
Ezh2 | Hdac2 | ENSRNOP00000008149 | ENSRNOP00000000742 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.992 |
Ezh2 | Ring1 | ENSRNOP00000008149 | ENSRNOP00000000543 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] | 0.936 |
Ezh2 | Rybp | ENSRNOP00000008149 | ENSRNOP00000007185 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | RING1 and YY1-binding protein. | 0.608 |
Ezh2 | Sirt1 | ENSRNOP00000008149 | ENSRNOP00000070943 | Similar to Enhancer of zeste homolog 2 (ENX-1), isoform CRA_b. | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...] | 0.922 |