node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Phf5a | Rbmx2 | ENSRNOP00000005837 | ENSRNOP00000043159 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | 0.992 |
Phf5a | Sf3a2 | ENSRNOP00000005837 | ENSRNOP00000026202 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3A subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron. | 0.993 |
Phf5a | Sf3b1 | ENSRNOP00000005837 | ENSRNOP00000019126 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3b, subunit 1, isoform CRA_b. | 0.998 |
Phf5a | Sf3b2 | ENSRNOP00000005837 | ENSRNOP00000060335 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3b, subunit 2. | 0.999 |
Phf5a | Sf3b3 | ENSRNOP00000005837 | ENSRNOP00000023854 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3b, subunit 3. | 0.999 |
Phf5a | Sf3b4 | ENSRNOP00000005837 | ENSRNOP00000028758 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class [...] | 0.998 |
Phf5a | Sf3b5 | ENSRNOP00000005837 | ENSRNOP00000019994 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. | 0.999 |
Phf5a | Sf3b6 | ENSRNOP00000005837 | ENSRNOP00000065625 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Splicing factor 3B, subunit 6. | 0.996 |
Phf5a | Snrnp200 | ENSRNOP00000005837 | ENSRNOP00000048598 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.989 |
Phf5a | Snrpf | ENSRNOP00000005837 | ENSRNOP00000007351 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | Small nuclear ribonucleoprotein polypeptide F. | 0.991 |
Rbmx2 | Phf5a | ENSRNOP00000043159 | ENSRNOP00000005837 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] | 0.992 |
Rbmx2 | Sf3a2 | ENSRNOP00000043159 | ENSRNOP00000026202 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3A subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron. | 0.974 |
Rbmx2 | Sf3b1 | ENSRNOP00000043159 | ENSRNOP00000019126 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3b, subunit 1, isoform CRA_b. | 0.991 |
Rbmx2 | Sf3b2 | ENSRNOP00000043159 | ENSRNOP00000060335 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3b, subunit 2. | 0.990 |
Rbmx2 | Sf3b3 | ENSRNOP00000043159 | ENSRNOP00000023854 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3b, subunit 3. | 0.990 |
Rbmx2 | Sf3b4 | ENSRNOP00000043159 | ENSRNOP00000028758 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class [...] | 0.989 |
Rbmx2 | Sf3b5 | ENSRNOP00000043159 | ENSRNOP00000019994 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. | 0.966 |
Rbmx2 | Sf3b6 | ENSRNOP00000043159 | ENSRNOP00000065625 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Splicing factor 3B, subunit 6. | 0.789 |
Rbmx2 | Snrnp200 | ENSRNOP00000043159 | ENSRNOP00000048598 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.987 |
Rbmx2 | Snrpf | ENSRNOP00000043159 | ENSRNOP00000007351 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Small nuclear ribonucleoprotein polypeptide F. | 0.939 |