STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pou6f1POU domain, class 6, transcription factor 1; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'); Belongs to the POU transcription factor family. Class- 6 subfamily (301 aa)    
Predicted Functional Partners:
Opa3
Optic atrophy 3 (Autosomal recessive, with chorea and spastic paraplegia) (Predicted); Optic atrophy 3
      
 0.718
Pou2af1
POU class 2 associating factor 1
    
 
 0.635
Farsa
phenylalanyl-tRNA synthetase, alpha subunit
      
 0.634
Nyap1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
   
  
 0.624
Mitd1
MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT complexes. Seems not to be involved in endosomal transport (By similarity)
      
 0.590
Onecut1
Hepatocyte nuclear factor 6; Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. The affinity of HNF-6-alpha and HNF-6-beta for DNA differs depending on the target sequence
   
 
 0.588
Klf16
Kruppel-like factor 16
   
 
 0.563
ENSRNOG00000050511
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
   
  
 0.561
Lhx3
RCG45383, isoform CRA_b; LIM homeobox 3
   
 
 0.547
Isl2
Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways
   
 
 0.538
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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