node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Map2k3 | Map2k6 | ENSRNOP00000008679 | ENSRNOP00000006217 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | 0.953 |
Map2k3 | Map3k5 | ENSRNOP00000008679 | ENSRNOP00000051338 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 5. | 0.956 |
Map2k3 | Map3k7 | ENSRNOP00000008679 | ENSRNOP00000007654 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.950 |
Map2k3 | Mapk1 | ENSRNOP00000008679 | ENSRNOP00000002533 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.951 |
Map2k3 | Mapk11 | ENSRNOP00000008679 | ENSRNOP00000009325 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.971 |
Map2k3 | Mapk12 | ENSRNOP00000008679 | ENSRNOP00000046455 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | 0.964 |
Map2k3 | Mapk13 | ENSRNOP00000008679 | ENSRNOP00000000621 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.963 |
Map2k3 | Mapk14 | ENSRNOP00000008679 | ENSRNOP00000000617 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.999 |
Map2k3 | Mapk3 | ENSRNOP00000008679 | ENSRNOP00000070784 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.972 |
Map2k3 | Tab1 | ENSRNOP00000008679 | ENSRNOP00000075816 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.961 |
Map2k6 | Map2k3 | ENSRNOP00000006217 | ENSRNOP00000008679 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | 0.953 |
Map2k6 | Map3k5 | ENSRNOP00000006217 | ENSRNOP00000051338 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 5. | 0.969 |
Map2k6 | Map3k7 | ENSRNOP00000006217 | ENSRNOP00000007654 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.978 |
Map2k6 | Mapk1 | ENSRNOP00000006217 | ENSRNOP00000002533 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.945 |
Map2k6 | Mapk11 | ENSRNOP00000006217 | ENSRNOP00000009325 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.969 |
Map2k6 | Mapk12 | ENSRNOP00000006217 | ENSRNOP00000046455 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | 0.962 |
Map2k6 | Mapk13 | ENSRNOP00000006217 | ENSRNOP00000000621 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.962 |
Map2k6 | Mapk14 | ENSRNOP00000006217 | ENSRNOP00000000617 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.979 |
Map2k6 | Mapk3 | ENSRNOP00000006217 | ENSRNOP00000070784 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.951 |
Map2k6 | Tab1 | ENSRNOP00000006217 | ENSRNOP00000075816 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.946 |