STRINGSTRING
Klhdc2 protein (Rattus norvegicus) - STRING interaction network
"Klhdc2" - Kelch domain-containing protein 2 in Rattus norvegicus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Klhdc2Kelch domain-containing protein 2 ; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding (406 aa)    
Predicted Functional Partners:
Klhl6
Kelch-like protein 6 (619 aa)
     
   
  0.689
Klhdc7a
Kelch domain containing 7A (773 aa)
           
  0.673
Myo9b
Unconventional myosin-IXb ; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA (PubMed-7882973). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation o [...] (1988 aa)
     
 
  0.620
Myo9a
Unconventional myosin-IXa ; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it’s GTPase activity in neurons, has a role in the regulation of neuronal morphology and function (2626 aa)
     
 
  0.620
Klhl3
Kelch-like family member 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity) (407 aa)
     
   
  0.617
Myo10
Unconventional myosin-X ; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by tra [...] (2060 aa)
     
      0.601
Myo3b
myosin-IIIb (1298 aa)
     
      0.601
Myo3a
Protein Myo3a (1621 aa)
     
      0.601
Myo15
Myosin XV (3504 aa)
     
      0.601
Myo7b
myosin-VIIb (2152 aa)
     
      0.601
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (35%) [HD]