node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cel | Cela1 | ENSRNOP00000014572 | ENSRNOP00000006351 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Chymotrypsin-like elastase family member 1; Acts upon elastin. | 0.686 |
Cel | Cpa1 | ENSRNOP00000014572 | ENSRNOP00000014465 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.986 |
Cel | Cpa2 | ENSRNOP00000014572 | ENSRNOP00000038495 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Carboxypeptidase A2. | 0.648 |
Cel | Cpb1 | ENSRNOP00000014572 | ENSRNOP00000048109 | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | Carboxypeptidase B. | 0.953 |
Cela1 | Cel | ENSRNOP00000006351 | ENSRNOP00000014572 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | 0.686 |
Cela1 | Cpa1 | ENSRNOP00000006351 | ENSRNOP00000014465 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | 0.759 |
Cela1 | Cpa2 | ENSRNOP00000006351 | ENSRNOP00000038495 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Carboxypeptidase A2. | 0.711 |
Cela1 | Cpb1 | ENSRNOP00000006351 | ENSRNOP00000048109 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Carboxypeptidase B. | 0.623 |
Cela1 | Ptf1a | ENSRNOP00000006351 | ENSRNOP00000022727 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.610 |
Cela1 | Serpina1 | ENSRNOP00000006351 | ENSRNOP00000070937 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Alpha-1-antiproteinase; Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin; Belongs to the serpin family. | 0.644 |
Cela1 | Serpina16 | ENSRNOP00000006351 | ENSRNOP00000030237 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16; Belongs to the serpin family. | 0.616 |
Cela1 | Serpina1f | ENSRNOP00000006351 | ENSRNOP00000054139 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Serine (or cysteine) peptidase inhibitor, clade A, member 1F; Belongs to the serpin family. | 0.616 |
Cela1 | Spink1 | ENSRNOP00000006351 | ENSRNOP00000017969 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). | 0.579 |
Cela1 | Spink3 | ENSRNOP00000006351 | ENSRNOP00000018110 | Chymotrypsin-like elastase family member 1; Acts upon elastin. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). | 0.625 |
Cpa1 | Cel | ENSRNOP00000014465 | ENSRNOP00000014572 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). ECO:0000250|UniProtKB:Q64285. | 0.986 |
Cpa1 | Cela1 | ENSRNOP00000014465 | ENSRNOP00000006351 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Chymotrypsin-like elastase family member 1; Acts upon elastin. | 0.759 |
Cpa1 | Cpa2 | ENSRNOP00000014465 | ENSRNOP00000038495 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Carboxypeptidase A2. | 0.953 |
Cpa1 | Cpb1 | ENSRNOP00000014465 | ENSRNOP00000048109 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Carboxypeptidase B. | 0.979 |
Cpa1 | Ptf1a | ENSRNOP00000014465 | ENSRNOP00000022727 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.774 |
Cpa1 | Spink1 | ENSRNOP00000014465 | ENSRNOP00000017969 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). | 0.575 |