node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmi1 | Kdm2b | ENSRNOP00000059998 | ENSRNOP00000050408 | BMI1 proto-oncogene, polycomb ring finger. | Lysine demethylase 2B. | 0.822 |
Bmi1 | L3mbtl2 | ENSRNOP00000059998 | ENSRNOP00000031908 | BMI1 proto-oncogene, polycomb ring finger. | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | 0.549 |
Bmi1 | Pcgf1 | ENSRNOP00000059998 | ENSRNOP00000011173 | BMI1 proto-oncogene, polycomb ring finger. | Polycomb group RING finger protein 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell p [...] | 0.887 |
Bmi1 | Pcgf3 | ENSRNOP00000059998 | ENSRNOP00000000071 | BMI1 proto-oncogene, polycomb ring finger. | Polycomb group ring finger 3. | 0.801 |
Bmi1 | Pcgf5 | ENSRNOP00000059998 | ENSRNOP00000074710 | BMI1 proto-oncogene, polycomb ring finger. | Polycomb group ring finger 5. | 0.786 |
Bmi1 | Pcgf6 | ENSRNOP00000059998 | ENSRNOP00000027450 | BMI1 proto-oncogene, polycomb ring finger. | Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 [...] | 0.861 |
Bmi1 | Ring1 | ENSRNOP00000059998 | ENSRNOP00000000543 | BMI1 proto-oncogene, polycomb ring finger. | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] | 0.999 |
Bmi1 | Rnf2 | ENSRNOP00000059998 | ENSRNOP00000068794 | BMI1 proto-oncogene, polycomb ring finger. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.999 |
Bmi1 | Rybp | ENSRNOP00000059998 | ENSRNOP00000007185 | BMI1 proto-oncogene, polycomb ring finger. | RING1 and YY1-binding protein. | 0.972 |
Bmi1 | Yaf2 | ENSRNOP00000059998 | ENSRNOP00000006621 | BMI1 proto-oncogene, polycomb ring finger. | YY1-associated factor 2. | 0.917 |
Kdm2b | Bmi1 | ENSRNOP00000050408 | ENSRNOP00000059998 | Lysine demethylase 2B. | BMI1 proto-oncogene, polycomb ring finger. | 0.822 |
Kdm2b | Pcgf1 | ENSRNOP00000050408 | ENSRNOP00000011173 | Lysine demethylase 2B. | Polycomb group RING finger protein 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell p [...] | 0.961 |
Kdm2b | Pcgf3 | ENSRNOP00000050408 | ENSRNOP00000000071 | Lysine demethylase 2B. | Polycomb group ring finger 3. | 0.735 |
Kdm2b | Pcgf5 | ENSRNOP00000050408 | ENSRNOP00000074710 | Lysine demethylase 2B. | Polycomb group ring finger 5. | 0.689 |
Kdm2b | Pcgf6 | ENSRNOP00000050408 | ENSRNOP00000027450 | Lysine demethylase 2B. | Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 [...] | 0.794 |
Kdm2b | Ring1 | ENSRNOP00000050408 | ENSRNOP00000000543 | Lysine demethylase 2B. | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] | 0.966 |
Kdm2b | Rnf2 | ENSRNOP00000050408 | ENSRNOP00000068794 | Lysine demethylase 2B. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.986 |
Kdm2b | Rybp | ENSRNOP00000050408 | ENSRNOP00000007185 | Lysine demethylase 2B. | RING1 and YY1-binding protein. | 0.965 |
Kdm2b | Yaf2 | ENSRNOP00000050408 | ENSRNOP00000006621 | Lysine demethylase 2B. | YY1-associated factor 2. | 0.927 |
L3mbtl2 | Bmi1 | ENSRNOP00000031908 | ENSRNOP00000059998 | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | BMI1 proto-oncogene, polycomb ring finger. | 0.549 |