node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agmat | Amdhd1 | ENSRNOP00000016646 | ENSRNOP00000007331 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amidohydrolase domain-containing 1. | 0.489 |
Agmat | Arg1 | ENSRNOP00000016646 | ENSRNOP00000017911 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.540 |
Agmat | Arg2 | ENSRNOP00000016646 | ENSRNOP00000073568 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.541 |
Agmat | Ftcd | ENSRNOP00000016646 | ENSRNOP00000001699 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family. | 0.494 |
Agmat | Hal | ENSRNOP00000016646 | ENSRNOP00000006971 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.823 |
Agmat | Uroc1 | ENSRNOP00000016646 | ENSRNOP00000032936 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Urocanate hydratase 1. | 0.437 |
Amdhd1 | Agmat | ENSRNOP00000007331 | ENSRNOP00000016646 | Amidohydrolase domain-containing 1. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.489 |
Amdhd1 | Ftcd | ENSRNOP00000007331 | ENSRNOP00000001699 | Amidohydrolase domain-containing 1. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family. | 0.988 |
Amdhd1 | Hal | ENSRNOP00000007331 | ENSRNOP00000006971 | Amidohydrolase domain-containing 1. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.946 |
Amdhd1 | Uroc1 | ENSRNOP00000007331 | ENSRNOP00000032936 | Amidohydrolase domain-containing 1. | Urocanate hydratase 1. | 0.994 |
Arg1 | Agmat | ENSRNOP00000017911 | ENSRNOP00000016646 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.540 |
Arg1 | Arg2 | ENSRNOP00000017911 | ENSRNOP00000073568 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.910 |
Arg1 | Hal | ENSRNOP00000017911 | ENSRNOP00000006971 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.856 |
Arg2 | Agmat | ENSRNOP00000073568 | ENSRNOP00000016646 | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.541 |
Arg2 | Arg1 | ENSRNOP00000073568 | ENSRNOP00000017911 | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.910 |
Arg2 | Hal | ENSRNOP00000073568 | ENSRNOP00000006971 | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.823 |
Carns1 | Cndp1 | ENSRNOP00000062149 | ENSRNOP00000034652 | Carnosine synthase 1. | Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family. | 0.959 |
Carns1 | Cndp2 | ENSRNOP00000062149 | ENSRNOP00000021400 | Carnosine synthase 1. | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis; Belongs to the peptidase M20A family. | 0.956 |
Carns1 | Hal | ENSRNOP00000062149 | ENSRNOP00000006971 | Carnosine synthase 1. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.905 |
Carns1 | Hdc | ENSRNOP00000062149 | ENSRNOP00000041885 | Carnosine synthase 1. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family. | 0.909 |