STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Shmt1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (681 aa)    
Predicted Functional Partners:
Gart
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
  
 0.999
Mthfr
Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.996
Mthfd2
RCG56426.
  
 0.995
Atic
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.
  
 0.995
Mthfd1
C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.
  
 0.994
Dhfr
Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).
  
 
 0.994
Mthfd2l
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
  
 0.994
Psph
Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family.
  
 0.993
Tyms
Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
  
 
 0.993
Sardh
Sarcosine dehydrogenase, mitochondrial.
  
 0.992
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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