node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fancm | Fbh1 | ENSRNOP00000074177 | ENSRNOP00000025228 | FA complementation group M. | F-box only protein 18 (Predicted). | 0.982 |
Fancm | Mus81 | ENSRNOP00000074177 | ENSRNOP00000028015 | FA complementation group M. | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.997 |
Fancm | Rad51 | ENSRNOP00000074177 | ENSRNOP00000053270 | FA complementation group M. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.930 |
Fancm | Rad52 | ENSRNOP00000074177 | ENSRNOP00000013070 | FA complementation group M. | RAD52 homolog, DNA repair protein. | 0.990 |
Fancm | Recql5 | ENSRNOP00000074177 | ENSRNOP00000007246 | FA complementation group M. | ATP-dependent DNA helicase Q5; DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity). Belongs to the helica [...] | 0.994 |
Fancm | Rmi1 | ENSRNOP00000074177 | ENSRNOP00000025812 | FA complementation group M. | RecQ mediated genome instability 1. | 0.993 |
Fancm | Slc25a16 | ENSRNOP00000074177 | ENSRNOP00000000438 | FA complementation group M. | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavag [...] | 0.755 |
Fancm | Slx1b | ENSRNOP00000074177 | ENSRNOP00000026231 | FA complementation group M. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.927 |
Fancm | Smarcal1 | ENSRNOP00000074177 | ENSRNOP00000022459 | FA complementation group M. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks ( [...] | 0.858 |
Fancm | Top3a | ENSRNOP00000074177 | ENSRNOP00000061212 | FA complementation group M. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.990 |
Fbh1 | Fancm | ENSRNOP00000025228 | ENSRNOP00000074177 | F-box only protein 18 (Predicted). | FA complementation group M. | 0.982 |
Fbh1 | Mus81 | ENSRNOP00000025228 | ENSRNOP00000028015 | F-box only protein 18 (Predicted). | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.880 |
Fbh1 | Rad51 | ENSRNOP00000025228 | ENSRNOP00000053270 | F-box only protein 18 (Predicted). | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.942 |
Fbh1 | Rad52 | ENSRNOP00000025228 | ENSRNOP00000013070 | F-box only protein 18 (Predicted). | RAD52 homolog, DNA repair protein. | 0.903 |
Fbh1 | Recql5 | ENSRNOP00000025228 | ENSRNOP00000007246 | F-box only protein 18 (Predicted). | ATP-dependent DNA helicase Q5; DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity). Belongs to the helica [...] | 0.898 |
Fbh1 | Rmi1 | ENSRNOP00000025228 | ENSRNOP00000025812 | F-box only protein 18 (Predicted). | RecQ mediated genome instability 1. | 0.589 |
Fbh1 | Slc25a16 | ENSRNOP00000025228 | ENSRNOP00000000438 | F-box only protein 18 (Predicted). | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavag [...] | 0.759 |
Fbh1 | Smarcal1 | ENSRNOP00000025228 | ENSRNOP00000022459 | F-box only protein 18 (Predicted). | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks ( [...] | 0.714 |
Fbh1 | Top3a | ENSRNOP00000025228 | ENSRNOP00000061212 | F-box only protein 18 (Predicted). | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.828 |
Mus81 | Fancm | ENSRNOP00000028015 | ENSRNOP00000074177 | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | FA complementation group M. | 0.997 |