STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmx2Thioredoxin-related transmembrane protein 2. (295 aa)    
Predicted Functional Partners:
Tmx1
Thioredoxin-related transmembrane protein 1.
    
 
 0.683
Tmx4
Thioredoxin-related transmembrane protein 4.
    
 
 0.657
Tmx3
Thioredoxin-related transmembrane protein 3.
    
 
 0.645
Erp27
Similar to RIKEN cDNA 1810033M07 (Predicted).
    
 
 0.508
Agr3
Anterior gradient 3, protein disulphide isomerase family member.
      
 0.491
Erp29
Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
      
 0.488
Pdia5
Protein disulfide-isomerase A5; Belongs to the protein disulfide isomerase family.
    
 
 0.473
Dnajc15
DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a.
      
 0.471
Erp44
Endoplasmic reticulum protein 44.
    
 
 0.422
Canx
Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...]
   
 
 0.421
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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