node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agmat | Amd1 | ENSRNOP00000016646 | ENSRNOP00000000715 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | 0.797 |
Agmat | Azin1 | ENSRNOP00000016646 | ENSRNOP00000007999 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. | 0.746 |
Agmat | LOC100912604 | ENSRNOP00000016646 | ENSRNOP00000067465 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine synthase. | 0.874 |
Agmat | Oat | ENSRNOP00000016646 | ENSRNOP00000022628 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine aminotransferase, mitochondrial. | 0.937 |
Agmat | Oaz2 | ENSRNOP00000016646 | ENSRNOP00000021372 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine decarboxylase antizyme 2. | 0.408 |
Agmat | Smox | ENSRNOP00000016646 | ENSRNOP00000028876 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | RCG27151, isoform CRA_a. | 0.556 |
Agmat | Sms | ENSRNOP00000016646 | ENSRNOP00000010135 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermine synthase. | 0.870 |
Agmat | Srm | ENSRNOP00000016646 | ENSRNOP00000014934 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.986 |
Amd1 | Agmat | ENSRNOP00000000715 | ENSRNOP00000016646 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.797 |
Amd1 | Azin1 | ENSRNOP00000000715 | ENSRNOP00000007999 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. | 0.742 |
Amd1 | LOC100912604 | ENSRNOP00000000715 | ENSRNOP00000067465 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermidine synthase. | 0.941 |
Amd1 | Oat | ENSRNOP00000000715 | ENSRNOP00000022628 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine aminotransferase, mitochondrial. | 0.608 |
Amd1 | Oaz1 | ENSRNOP00000000715 | ENSRNOP00000026341 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome- interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination (By similarity). Also i [...] | 0.553 |
Amd1 | Oaz2 | ENSRNOP00000000715 | ENSRNOP00000021372 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine decarboxylase antizyme 2. | 0.707 |
Amd1 | Oaz3 | ENSRNOP00000000715 | ENSRNOP00000028303 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | 0.565 |
Amd1 | Smox | ENSRNOP00000000715 | ENSRNOP00000028876 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | RCG27151, isoform CRA_a. | 0.818 |
Amd1 | Sms | ENSRNOP00000000715 | ENSRNOP00000010135 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermine synthase. | 0.994 |
Amd1 | Srm | ENSRNOP00000000715 | ENSRNOP00000014934 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.995 |
Azin1 | Agmat | ENSRNOP00000007999 | ENSRNOP00000016646 | Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.746 |
Azin1 | Amd1 | ENSRNOP00000007999 | ENSRNOP00000000715 | Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | 0.742 |