STRINGSTRING
Tmem106b protein (Rattus norvegicus) - STRING interaction network
"Tmem106b" - Transmembrane protein 106B in Rattus norvegicus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmem106bTransmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching; Belongs to the TMEM106 family (275 aa)    
Predicted Functional Partners:
Map6
Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (525 aa)
       
 
  0.814
Chmp2b
Charged multivesicular body protein 2B; Belongs to the SNF7 family (213 aa)
     
 
  0.725
Arl8b
ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation (186 aa)
     
   
  0.706
Rfc5
Replication factor C (activator 1) 5 (338 aa)
           
  0.682
Grn
Granulins; Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling (602 aa)
           
  0.673
Pld3
Phospholipase D3; May be involved in APP processing (488 aa)
     
   
  0.666
Yipf4
Protein YIPF4; Involved in the maintenance of the Golgi structure (246 aa)
     
        0.661
Sort1
Sortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differ [...] (825 aa)
     
   
  0.640
Lamp1
Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis (407 aa)
     
 
  0.636
Fbxo38
F-box protein 38 (1189 aa)
           
  0.591
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (7%) [HD]