node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A0G2JVI0_RAT | Clpb | ENSRNOP00000069492 | ENSRNOP00000072796 | Uncharacterized protein; Belongs to the GroES chaperonin family. | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 0.807 |
A0A0G2JVI0_RAT | Grpel1 | ENSRNOP00000069492 | ENSRNOP00000070967 | Uncharacterized protein; Belongs to the GroES chaperonin family. | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | 0.842 |
A0A0G2JVI0_RAT | Hspa9 | ENSRNOP00000069492 | ENSRNOP00000026696 | Uncharacterized protein; Belongs to the GroES chaperonin family. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | 0.823 |
Clpb | A0A0G2JVI0_RAT | ENSRNOP00000072796 | ENSRNOP00000069492 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Uncharacterized protein; Belongs to the GroES chaperonin family. | 0.807 |
Clpb | Grpel1 | ENSRNOP00000072796 | ENSRNOP00000070967 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | 0.942 |
Clpb | Hspa9 | ENSRNOP00000072796 | ENSRNOP00000026696 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | 0.860 |
Clpb | Hspe1 | ENSRNOP00000072796 | ENSRNOP00000068700 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 10 kDa heat shock protein, mitochondrial; Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per [...] | 0.849 |
Dnajc15 | Grpel1 | ENSRNOP00000012530 | ENSRNOP00000070967 | DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a. | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | 0.885 |
Dnajc15 | Hspa9 | ENSRNOP00000012530 | ENSRNOP00000026696 | DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | 0.873 |
Dnajc15 | Pam16 | ENSRNOP00000012530 | ENSRNOP00000006314 | DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a. | Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity); Belongs to the TIM16/PAM16 family. | 0.978 |
Dnajc15 | Timm17a | ENSRNOP00000012530 | ENSRNOP00000009398 | DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a. | Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.869 |
Dnajc15 | Timm44 | ENSRNOP00000012530 | ENSRNOP00000001409 | DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a. | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source. | 0.852 |
Grpel1 | A0A0G2JVI0_RAT | ENSRNOP00000070967 | ENSRNOP00000069492 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | Uncharacterized protein; Belongs to the GroES chaperonin family. | 0.842 |
Grpel1 | Clpb | ENSRNOP00000070967 | ENSRNOP00000072796 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 0.942 |
Grpel1 | Dnajc15 | ENSRNOP00000070967 | ENSRNOP00000012530 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | DnaJ (Hsp40) homolog, subfamily C, member 15 (Predicted), isoform CRA_a. | 0.885 |
Grpel1 | Hspa9 | ENSRNOP00000070967 | ENSRNOP00000026696 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | 0.976 |
Grpel1 | Hspe1 | ENSRNOP00000070967 | ENSRNOP00000068700 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | 10 kDa heat shock protein, mitochondrial; Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per [...] | 0.881 |
Grpel1 | Mrpl30 | ENSRNOP00000070967 | ENSRNOP00000067807 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | 39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family. | 0.831 |
Grpel1 | Ndufa9 | ENSRNOP00000070967 | ENSRNOP00000072757 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.851 |
Grpel1 | Pam16 | ENSRNOP00000070967 | ENSRNOP00000006314 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins; Belongs to the GrpE family. | Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity); Belongs to the TIM16/PAM16 family. | 0.939 |