node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btrc | Chuk | ENSRNOP00000022426 | ENSRNOP00000034134 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.750 |
Btrc | Ikbkb | ENSRNOP00000022426 | ENSRNOP00000025851 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.655 |
Btrc | Ikbkg | ENSRNOP00000022426 | ENSRNOP00000075158 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.413 |
Btrc | Nfkb1 | ENSRNOP00000022426 | ENSRNOP00000028944 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | 0.796 |
Btrc | Nfkb2 | ENSRNOP00000022426 | ENSRNOP00000026235 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | 0.839 |
Btrc | Nfkbia | ENSRNOP00000022426 | ENSRNOP00000009894 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity). | 0.994 |
Btrc | Nfkbib | ENSRNOP00000022426 | ENSRNOP00000027212 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. | 0.844 |
Btrc | Rela | ENSRNOP00000022426 | ENSRNOP00000044552 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.724 |
Btrc | Skp1 | ENSRNOP00000022426 | ENSRNOP00000073214 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Chuk | Btrc | ENSRNOP00000034134 | ENSRNOP00000022426 | Component of inhibitor of nuclear factor kappa B kinase complex. | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | 0.750 |
Chuk | Ikbkb | ENSRNOP00000034134 | ENSRNOP00000025851 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.999 |
Chuk | Ikbkg | ENSRNOP00000034134 | ENSRNOP00000075158 | Component of inhibitor of nuclear factor kappa B kinase complex. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.999 |
Chuk | Nfkb1 | ENSRNOP00000034134 | ENSRNOP00000028944 | Component of inhibitor of nuclear factor kappa B kinase complex. | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | 0.995 |
Chuk | Nfkb2 | ENSRNOP00000034134 | ENSRNOP00000026235 | Component of inhibitor of nuclear factor kappa B kinase complex. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a. | 0.984 |
Chuk | Nfkbia | ENSRNOP00000034134 | ENSRNOP00000009894 | Component of inhibitor of nuclear factor kappa B kinase complex. | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity). | 0.998 |
Chuk | Nfkbib | ENSRNOP00000034134 | ENSRNOP00000027212 | Component of inhibitor of nuclear factor kappa B kinase complex. | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. | 0.987 |
Chuk | Rel | ENSRNOP00000034134 | ENSRNOP00000072332 | Component of inhibitor of nuclear factor kappa B kinase complex. | REL proto-oncogene, NF-kB subunit. | 0.818 |
Chuk | Rela | ENSRNOP00000034134 | ENSRNOP00000044552 | Component of inhibitor of nuclear factor kappa B kinase complex. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.992 |
Chuk | Skp1 | ENSRNOP00000034134 | ENSRNOP00000073214 | Component of inhibitor of nuclear factor kappa B kinase complex. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.606 |
Ikbkb | Btrc | ENSRNOP00000025851 | ENSRNOP00000022426 | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | 0.655 |