node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alx1 | Npbwr1 | ENSRNOP00000006007 | ENSRNOP00000010032 | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). Belongs to the paired homeobox family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.452 |
Alx1 | Pcdhgb6 | ENSRNOP00000006007 | ENSRNOP00000057210 | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). Belongs to the paired homeobox family. | Protocadherin gamma subfamily B, 6. | 0.567 |
Gamt | Npbwr1 | ENSRNOP00000036927 | ENSRNOP00000010032 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.459 |
LOC100912228 | Npbwr1 | ENSRNOP00000066713 | ENSRNOP00000010032 | Neuropeptide Y. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.546 |
LOC100912228 | Pomc | ENSRNOP00000066713 | ENSRNOP00000016976 | Neuropeptide Y. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.950 |
Npb | Npbwr1 | ENSRNOP00000051836 | ENSRNOP00000010032 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity). | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.999 |
Npb | Npw | ENSRNOP00000051836 | ENSRNOP00000016554 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity). | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release; Belongs to the neuropeptide B/W family. | 0.994 |
Npbwr1 | Alx1 | ENSRNOP00000010032 | ENSRNOP00000006007 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). Belongs to the paired homeobox family. | 0.452 |
Npbwr1 | Gamt | ENSRNOP00000010032 | ENSRNOP00000036927 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | 0.459 |
Npbwr1 | LOC100912228 | ENSRNOP00000010032 | ENSRNOP00000066713 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Neuropeptide Y. | 0.546 |
Npbwr1 | Npb | ENSRNOP00000010032 | ENSRNOP00000051836 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity). | 0.999 |
Npbwr1 | Npw | ENSRNOP00000010032 | ENSRNOP00000016554 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release; Belongs to the neuropeptide B/W family. | 0.999 |
Npbwr1 | Npy | ENSRNOP00000010032 | ENSRNOP00000013146 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.546 |
Npbwr1 | Pcdhgb6 | ENSRNOP00000010032 | ENSRNOP00000057210 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Protocadherin gamma subfamily B, 6. | 0.575 |
Npbwr1 | Pomc | ENSRNOP00000010032 | ENSRNOP00000016976 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.452 |
Npbwr1 | Prss45 | ENSRNOP00000010032 | ENSRNOP00000040152 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Inactive serine protease 45. | 0.540 |
Npbwr1 | Rxfp1 | ENSRNOP00000010032 | ENSRNOP00000033541 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.487 |
Npw | Npb | ENSRNOP00000016554 | ENSRNOP00000051836 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release; Belongs to the neuropeptide B/W family. | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity). | 0.994 |
Npw | Npbwr1 | ENSRNOP00000016554 | ENSRNOP00000010032 | Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release; Belongs to the neuropeptide B/W family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.999 |
Npy | Npbwr1 | ENSRNOP00000013146 | ENSRNOP00000010032 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.546 |