STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Zfp467Zinc finger protein 467; Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity). (594 aa)    
Predicted Functional Partners:
Gimd1
GTPase IMAP family member GIMD1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
      
 0.627
Wdr86
WD repeat domain 86.
    
 
 0.592
Atp6v0e2
V-type proton ATPase subunit e 2; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
   
  
 0.579
Plekha7
Pleckstrin homology domain-containing A7.
      
 0.526
Krba1
KRAB-A domain-containing 1.
   
  
 0.449
Asb10
Similar to ankyrin repeat-containing SOCS box protein 10 (Predicted).
    
 
 0.422
Rcbtb1
RCC1 and BTB domain-containing protein 1.
   
 
 0.419
Emid1
EMI domain-containing 1.
   
 
 0.413
Crygn
Gamma-crystallin N; Crystallins are the dominant structural components of the vertebrate eye lens. Plays also an important role for integrity and function of auditory nuclei; Belongs to the beta/gamma-crystallin family.
    
 
 0.406
Rbbp9
Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet (By similarity). May negatively regulate basal or autocrine TGF- beta signaling by suppressing SMAD2-SMAD3 phosphorylation (By similarity). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF- beta through interaction with RB1 and the subsequent displacement of E2F1 ; Belongs to the RBBP9 family.
   
  
 0.402
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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