node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Astl | Nrdc | ENSRNOP00000037567 | ENSRNOP00000010462 | Metalloendopeptidase. | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | 0.608 |
Astl | Thop1 | ENSRNOP00000037567 | ENSRNOP00000027045 | Metalloendopeptidase. | Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. | 0.813 |
Hbegf | Ins1 | ENSRNOP00000025157 | ENSRNOP00000016052 | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.426 |
Hbegf | Nrdc | ENSRNOP00000025157 | ENSRNOP00000010462 | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | 0.907 |
Hbegf | Tgfa | ENSRNOP00000025157 | ENSRNOP00000054248 | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. | 0.878 |
Iapp | Ins1 | ENSRNOP00000016614 | ENSRNOP00000016052 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.922 |
Iapp | Nrdc | ENSRNOP00000016614 | ENSRNOP00000010462 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | 0.569 |
Ins1 | Hbegf | ENSRNOP00000016052 | ENSRNOP00000025157 | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). | 0.426 |
Ins1 | Iapp | ENSRNOP00000016052 | ENSRNOP00000016614 | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. | 0.922 |
Ins1 | Nrdc | ENSRNOP00000016052 | ENSRNOP00000010462 | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | 0.539 |
Ins1 | Tgfa | ENSRNOP00000016052 | ENSRNOP00000054248 | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. | 0.959 |
Nrdc | Astl | ENSRNOP00000010462 | ENSRNOP00000037567 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Metalloendopeptidase. | 0.608 |
Nrdc | Hbegf | ENSRNOP00000010462 | ENSRNOP00000025157 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). | 0.907 |
Nrdc | Iapp | ENSRNOP00000010462 | ENSRNOP00000016614 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. | 0.569 |
Nrdc | Ins1 | ENSRNOP00000010462 | ENSRNOP00000016052 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.539 |
Nrdc | Rnpep | ENSRNOP00000010462 | ENSRNOP00000009198 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)- somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4). | 0.547 |
Nrdc | Setx | ENSRNOP00000010462 | ENSRNOP00000017984 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Senataxin. | 0.558 |
Nrdc | Tgfa | ENSRNOP00000010462 | ENSRNOP00000054248 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. | 0.580 |
Nrdc | Thop1 | ENSRNOP00000010462 | ENSRNOP00000027045 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. | 0.554 |
Nrdc | Tll1 | ENSRNOP00000010462 | ENSRNOP00000058943 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. | Metalloendopeptidase. | 0.613 |