STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EhfEts homologous factor (Predicted), isoform CRA_b. (300 aa)    
Predicted Functional Partners:
RGD1359449
Gasdermin domain-containing protein RGD1359449.
      
 0.558
Zscan2
Zinc finger and SCAN domain-containing 2.
    
 
 0.551
Pdhx
Pyruvate dehydrogenase complex, component X.
      
 0.510
Sla
Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins (By similarity).
    
 
 0.499
Lad1
Ladinin-1; Anchoring filament protein which is a component of the basement membrane zone.
   
  
 0.490
Zfp202
Zinc finger protein 202.
    
 
 0.455
Prom2
Prominin-2.
  
  
 0.440
Grhl2
Grainyhead-like transcription factor 2.
   
  
 0.434
Prrg2
Proline-rich and Gla domain 2.
      
 0.432
Fem1b
Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet (By similarity). Functions as an adapter/mediator in replication stress- induced signaling that leads to the activation of CHEK1 (By similarity); Belongs to the fem-1 family.
    
 
 0.413
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.