node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atic | Dhfr | ENSRNOP00000021105 | ENSRNOP00000018259 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | 0.984 |
Atic | Gart | ENSRNOP00000021105 | ENSRNOP00000033253 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.999 |
Atic | Mthfd1 | ENSRNOP00000021105 | ENSRNOP00000008374 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. | 0.991 |
Atic | Mthfd1l | ENSRNOP00000021105 | ENSRNOP00000026564 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like. | 0.988 |
Atic | Mthfd2 | ENSRNOP00000021105 | ENSRNOP00000014603 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | RCG56426. | 0.988 |
Atic | Mthfd2l | ENSRNOP00000021105 | ENSRNOP00000044342 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.984 |
Atic | Mthfr | ENSRNOP00000021105 | ENSRNOP00000011384 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.778 |
Atic | Psph | ENSRNOP00000021105 | ENSRNOP00000001228 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. | 0.598 |
Atic | Shmt2 | ENSRNOP00000021105 | ENSRNOP00000011082 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.994 |
Atic | Tyms | ENSRNOP00000021105 | ENSRNOP00000053086 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.851 |
Dhfr | Atic | ENSRNOP00000018259 | ENSRNOP00000021105 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.984 |
Dhfr | Gart | ENSRNOP00000018259 | ENSRNOP00000033253 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.982 |
Dhfr | Mthfd1 | ENSRNOP00000018259 | ENSRNOP00000008374 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family. | 0.985 |
Dhfr | Mthfd1l | ENSRNOP00000018259 | ENSRNOP00000026564 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like. | 0.976 |
Dhfr | Mthfd2 | ENSRNOP00000018259 | ENSRNOP00000014603 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | RCG56426. | 0.780 |
Dhfr | Mthfd2l | ENSRNOP00000018259 | ENSRNOP00000044342 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.763 |
Dhfr | Mthfr | ENSRNOP00000018259 | ENSRNOP00000011384 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.865 |
Dhfr | Psph | ENSRNOP00000018259 | ENSRNOP00000001228 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. | 0.480 |
Dhfr | Shmt2 | ENSRNOP00000018259 | ENSRNOP00000011082 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.992 |
Dhfr | Tyms | ENSRNOP00000018259 | ENSRNOP00000053086 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity). | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.999 |