STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GzmmGranzyme M; Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells (By similarity); Belongs to the peptidase S1 family. Granzyme subfamily. (264 aa)    
Predicted Functional Partners:
Rd3l
Hypothetical LOC314467 (Predicted).
      
 0.669
Prf1
Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Belongs to the complement C6/C7/C8/C9 family.
   
 
 0.649
Ctsc
Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).
   
  
 0.645
Ccnjl
Cyclin J-like; Belongs to the cyclin family.
      
 0.582
Serpinb9
Serine (Or cysteine) peptidase inhibitor, clade B, member 9; Belongs to the serpin family.
   
 
 0.549
Map6d1
MAP6 domain-containing 1.
      
 0.505
Nkg7
Natural killer cell group 7 sequence, isoform CRA_a.
   
  
 0.498
Rrh
Retinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.494
Dexi
Similar to MYLE protein (Dexamethasone-induced protein) (Predicted).
      
 0.464
Sdr39u1
Short chain dehydrogenase/reductase family 39U, member 1.
     
 0.456
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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