node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A0G2JUH9_RAT | Bnip3l | ENSRNOP00000069104 | ENSRNOP00000014798 | SKICH domain-containing protein. | BCL2/adenovirus E1B interacting protein 3-like. | 0.587 |
A0A0G2JUH9_RAT | Fkbp8 | ENSRNOP00000069104 | ENSRNOP00000074539 | SKICH domain-containing protein. | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). | 0.484 |
A0A0G2JUH9_RAT | Gabarap | ENSRNOP00000069104 | ENSRNOP00000023724 | SKICH domain-containing protein. | Gamma-aminobutyric acid receptor-associated protein; Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity). | 0.857 |
A0A0G2JUH9_RAT | Map1lc3b2 | ENSRNOP00000069104 | ENSRNOP00000075089 | SKICH domain-containing protein. | Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellit [...] | 0.876 |
A0A0G2JUH9_RAT | Nbr1 | ENSRNOP00000069104 | ENSRNOP00000028149 | SKICH domain-containing protein. | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. | 0.802 |
A0A0G2JUH9_RAT | Nipsnap1 | ENSRNOP00000069104 | ENSRNOP00000011158 | SKICH domain-containing protein. | Nipsnap homolog 1. | 0.587 |
A0A0G2JUH9_RAT | Sqstm1 | ENSRNOP00000069104 | ENSRNOP00000056021 | SKICH domain-containing protein. | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery (By similarity). Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth f [...] | 0.804 |
A0A0G2JUH9_RAT | Tax1bp1 | ENSRNOP00000069104 | ENSRNOP00000046052 | SKICH domain-containing protein. | Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). | 0.442 |
Bnip3l | A0A0G2JUH9_RAT | ENSRNOP00000014798 | ENSRNOP00000069104 | BCL2/adenovirus E1B interacting protein 3-like. | SKICH domain-containing protein. | 0.587 |
Bnip3l | Fkbp8 | ENSRNOP00000014798 | ENSRNOP00000074539 | BCL2/adenovirus E1B interacting protein 3-like. | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). | 0.714 |
Bnip3l | Gabarap | ENSRNOP00000014798 | ENSRNOP00000023724 | BCL2/adenovirus E1B interacting protein 3-like. | Gamma-aminobutyric acid receptor-associated protein; Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity). | 0.999 |
Bnip3l | Map1lc3b2 | ENSRNOP00000014798 | ENSRNOP00000075089 | BCL2/adenovirus E1B interacting protein 3-like. | Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellit [...] | 0.942 |
Bnip3l | Nbr1 | ENSRNOP00000014798 | ENSRNOP00000028149 | BCL2/adenovirus E1B interacting protein 3-like. | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. | 0.795 |
Bnip3l | Nipsnap1 | ENSRNOP00000014798 | ENSRNOP00000011158 | BCL2/adenovirus E1B interacting protein 3-like. | Nipsnap homolog 1. | 0.617 |
Bnip3l | Sqstm1 | ENSRNOP00000014798 | ENSRNOP00000056021 | BCL2/adenovirus E1B interacting protein 3-like. | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery (By similarity). Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth f [...] | 0.656 |
Bnip3l | Tax1bp1 | ENSRNOP00000014798 | ENSRNOP00000046052 | BCL2/adenovirus E1B interacting protein 3-like. | Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). | 0.647 |
Fkbp8 | A0A0G2JUH9_RAT | ENSRNOP00000074539 | ENSRNOP00000069104 | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). | SKICH domain-containing protein. | 0.484 |
Fkbp8 | Bnip3l | ENSRNOP00000074539 | ENSRNOP00000014798 | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). | BCL2/adenovirus E1B interacting protein 3-like. | 0.714 |
Fkbp8 | Gabarap | ENSRNOP00000074539 | ENSRNOP00000023724 | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). | Gamma-aminobutyric acid receptor-associated protein; Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity). | 0.832 |
Fkbp8 | Map1lc3b2 | ENSRNOP00000074539 | ENSRNOP00000075089 | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). | Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellit [...] | 0.542 |