node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccz1b | Plekhm1 | ENSRNOP00000001365 | ENSRNOP00000034752 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | 0.587 |
Ccz1b | Rab7a | ENSRNOP00000001365 | ENSRNOP00000016432 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.897 |
Ccz1b | Tbc1d2 | ENSRNOP00000001365 | ENSRNOP00000011714 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). | 0.519 |
Ccz1b | Tbc1d5 | ENSRNOP00000001365 | ENSRNOP00000074017 | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | TBC1 domain family, member 5. | 0.658 |
Cdc16 | Rab33b | ENSRNOP00000023736 | ENSRNOP00000017396 | CDC16 cell division cycle 16 homolog (S. cerevisiae). | RAB33B, member of RAS oncogene family (Predicted), isoform CRA_b. | 0.473 |
Cdc16 | Tbc1d2 | ENSRNOP00000023736 | ENSRNOP00000011714 | CDC16 cell division cycle 16 homolog (S. cerevisiae). | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). | 0.488 |
Cdc16 | Tbc1d20 | ENSRNOP00000023736 | ENSRNOP00000008713 | CDC16 cell division cycle 16 homolog (S. cerevisiae). | TBC1 domain family, member 20. | 0.538 |
Cdc16 | Tbc1d25 | ENSRNOP00000023736 | ENSRNOP00000007130 | CDC16 cell division cycle 16 homolog (S. cerevisiae). | Ornithine aminotransferase-like 1 (Predicted). | 0.670 |
Cdc16 | Tbc1d5 | ENSRNOP00000023736 | ENSRNOP00000074017 | CDC16 cell division cycle 16 homolog (S. cerevisiae). | TBC1 domain family, member 5. | 0.614 |
Lrrk1 | Plekhm1 | ENSRNOP00000016959 | ENSRNOP00000034752 | Leucine-rich repeat kinase 1. | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | 0.473 |
Lrrk1 | Tbc1d2 | ENSRNOP00000016959 | ENSRNOP00000011714 | Leucine-rich repeat kinase 1. | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). | 0.552 |
Plekhm1 | Ccz1b | ENSRNOP00000034752 | ENSRNOP00000001365 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | CCZ1 homolog B, vacuolar protein-trafficking and biogenesis-associated. | 0.587 |
Plekhm1 | Lrrk1 | ENSRNOP00000034752 | ENSRNOP00000016959 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | Leucine-rich repeat kinase 1. | 0.473 |
Plekhm1 | Rab7a | ENSRNOP00000034752 | ENSRNOP00000016432 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.638 |
Plekhm1 | Tbc1d2 | ENSRNOP00000034752 | ENSRNOP00000011714 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). | 0.471 |
Plekhm1 | Tbc1d5 | ENSRNOP00000034752 | ENSRNOP00000074017 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome perip [...] | TBC1 domain family, member 5. | 0.452 |
Rab33b | Cdc16 | ENSRNOP00000017396 | ENSRNOP00000023736 | RAB33B, member of RAS oncogene family (Predicted), isoform CRA_b. | CDC16 cell division cycle 16 homolog (S. cerevisiae). | 0.473 |
Rab33b | Tbc1d2 | ENSRNOP00000017396 | ENSRNOP00000011714 | RAB33B, member of RAS oncogene family (Predicted), isoform CRA_b. | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). | 0.475 |
Rab33b | Tbc1d20 | ENSRNOP00000017396 | ENSRNOP00000008713 | RAB33B, member of RAS oncogene family (Predicted), isoform CRA_b. | TBC1 domain family, member 20. | 0.563 |
Rab33b | Tbc1d25 | ENSRNOP00000017396 | ENSRNOP00000007130 | RAB33B, member of RAS oncogene family (Predicted), isoform CRA_b. | Ornithine aminotransferase-like 1 (Predicted). | 0.938 |