STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tnfsf15Tumor necrosis factor ligand superfamily member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation (By similarity). (270 aa)    
Predicted Functional Partners:
Tnfrsf25
Similar to tumor necrosis factor receptor superfamily, member 25, isoform CRA_a.
    
 0.974
Tnfrsf14
Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator).
   
 
 0.733
Ltbr
Lymphotoxin beta receptor (TNFR superfamily, member 3).
   
 
 0.704
Tnfsf8
Tumor necrosis factor ligand 3a; Belongs to the tumor necrosis factor family.
      
 0.701
Tnfsf9
Tumor necrosis factor (Ligand) superfamily, member 9; Belongs to the tumor necrosis factor family.
      
 0.599
Tnfrsf4
Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
      
 0.597
Tnfsf18
TNF superfamily member 18.
      
 0.584
Tnfsf4
Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family.
   
  
 0.576
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1.
      
 0.569
Il6
Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]
   
  
 0.550
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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