node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adprhl2 | Glmp | ENSRNOP00000014586 | ENSRNOP00000026152 | ADP-ribosylhydrolase like 2 (Predicted). | Glycosylated lysosomal membrane protein; Belongs to the GLMP family. | 0.678 |
Adprhl2 | Lrrc73 | ENSRNOP00000014586 | ENSRNOP00000057899 | ADP-ribosylhydrolase like 2 (Predicted). | Leucine-rich repeat-containing protein 73. | 0.695 |
Adprhl2 | Slc35f6 | ENSRNOP00000014586 | ENSRNOP00000012558 | ADP-ribosylhydrolase like 2 (Predicted). | Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). | 0.646 |
Adprhl2 | Tmem208 | ENSRNOP00000014586 | ENSRNOP00000021722 | ADP-ribosylhydrolase like 2 (Predicted). | Similar to HSPC171 protein (Predicted), isoform CRA_a. | 0.675 |
Faf2 | Mrpl58 | ENSRNOP00000068627 | ENSRNOP00000043868 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. | Mitochondrial ribosomal protein L58. | 0.579 |
Faf2 | Nudt3 | ENSRNOP00000068627 | ENSRNOP00000074608 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. | Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able t [...] | 0.579 |
Faf2 | Otud4 | ENSRNOP00000068627 | ENSRNOP00000024924 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. | OTU deubiquitinase 4. | 0.652 |
Faf2 | Slc35f6 | ENSRNOP00000068627 | ENSRNOP00000012558 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. | Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). | 0.766 |
Faf2 | Tmem208 | ENSRNOP00000068627 | ENSRNOP00000021722 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. | Similar to HSPC171 protein (Predicted), isoform CRA_a. | 0.405 |
Faf2 | Ubqln4 | ENSRNOP00000068627 | ENSRNOP00000026994 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. | Ubiquilin 4 (Predicted). | 0.626 |
Fbxo6 | Mrpl58 | ENSRNOP00000012301 | ENSRNOP00000043868 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | Mitochondrial ribosomal protein L58. | 0.534 |
Fbxo6 | Otud4 | ENSRNOP00000012301 | ENSRNOP00000024924 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | OTU deubiquitinase 4. | 0.640 |
Fbxo6 | Slc35f6 | ENSRNOP00000012301 | ENSRNOP00000012558 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). | 0.691 |
Fbxo6 | Ubqln4 | ENSRNOP00000012301 | ENSRNOP00000026994 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | Ubiquilin 4 (Predicted). | 0.593 |
Glmp | Adprhl2 | ENSRNOP00000026152 | ENSRNOP00000014586 | Glycosylated lysosomal membrane protein; Belongs to the GLMP family. | ADP-ribosylhydrolase like 2 (Predicted). | 0.678 |
Glmp | Lrrc73 | ENSRNOP00000026152 | ENSRNOP00000057899 | Glycosylated lysosomal membrane protein; Belongs to the GLMP family. | Leucine-rich repeat-containing protein 73. | 0.667 |
Glmp | Slc35f6 | ENSRNOP00000026152 | ENSRNOP00000012558 | Glycosylated lysosomal membrane protein; Belongs to the GLMP family. | Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). | 0.643 |
Glmp | Tmem208 | ENSRNOP00000026152 | ENSRNOP00000021722 | Glycosylated lysosomal membrane protein; Belongs to the GLMP family. | Similar to HSPC171 protein (Predicted), isoform CRA_a. | 0.646 |
Lrrc73 | Adprhl2 | ENSRNOP00000057899 | ENSRNOP00000014586 | Leucine-rich repeat-containing protein 73. | ADP-ribosylhydrolase like 2 (Predicted). | 0.695 |
Lrrc73 | Glmp | ENSRNOP00000057899 | ENSRNOP00000026152 | Leucine-rich repeat-containing protein 73. | Glycosylated lysosomal membrane protein; Belongs to the GLMP family. | 0.667 |