node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Foxb1 | Foxe1 | ENSRNOP00000014014 | ENSRNOP00000012637 | Forkhead box B1. | Forkhead box E1 (Thyroid transcription factor 2). | 0.604 |
Foxb1 | Nkx2-1 | ENSRNOP00000014014 | ENSRNOP00000011453 | Forkhead box B1. | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circad [...] | 0.410 |
Foxe1 | Foxb1 | ENSRNOP00000012637 | ENSRNOP00000014014 | Forkhead box E1 (Thyroid transcription factor 2). | Forkhead box B1. | 0.604 |
Foxe1 | Hhex | ENSRNOP00000012637 | ENSRNOP00000022384 | Forkhead box E1 (Thyroid transcription factor 2). | Hematopoietically-expressed homeobox. | 0.726 |
Foxe1 | Irf6 | ENSRNOP00000012637 | ENSRNOP00000007333 | Forkhead box E1 (Thyroid transcription factor 2). | Interferon regulatory factor 6 (Predicted). | 0.605 |
Foxe1 | Iyd | ENSRNOP00000012637 | ENSRNOP00000021893 | Forkhead box E1 (Thyroid transcription factor 2). | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. | 0.608 |
Foxe1 | Nkx2-1 | ENSRNOP00000012637 | ENSRNOP00000011453 | Forkhead box E1 (Thyroid transcription factor 2). | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circad [...] | 0.783 |
Foxe1 | Pax8 | ENSRNOP00000012637 | ENSRNOP00000033966 | Forkhead box E1 (Thyroid transcription factor 2). | Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity). | 0.807 |
Foxe1 | Slc5a5 | ENSRNOP00000012637 | ENSRNOP00000025577 | Forkhead box E1 (Thyroid transcription factor 2). | Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.714 |
Foxe1 | Tg | ENSRNOP00000012637 | ENSRNOP00000009241 | Forkhead box E1 (Thyroid transcription factor 2). | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). Belongs to the type-B carboxylesterase/lipase family. | 0.802 |
Foxe1 | Tpo | ENSRNOP00000012637 | ENSRNOP00000006526 | Forkhead box E1 (Thyroid transcription factor 2). | Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). | 0.676 |
Foxe1 | Tshr | ENSRNOP00000012637 | ENSRNOP00000005671 | Forkhead box E1 (Thyroid transcription factor 2). | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Plays a central role in controlling thyroid cell metabolism. | 0.749 |
Hhex | Foxe1 | ENSRNOP00000022384 | ENSRNOP00000012637 | Hematopoietically-expressed homeobox. | Forkhead box E1 (Thyroid transcription factor 2). | 0.726 |
Hhex | Pax8 | ENSRNOP00000022384 | ENSRNOP00000033966 | Hematopoietically-expressed homeobox. | Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity). | 0.628 |
Hhex | Slc5a5 | ENSRNOP00000022384 | ENSRNOP00000025577 | Hematopoietically-expressed homeobox. | Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.426 |
Hhex | Tg | ENSRNOP00000022384 | ENSRNOP00000009241 | Hematopoietically-expressed homeobox. | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). Belongs to the type-B carboxylesterase/lipase family. | 0.403 |
Hhex | Tshr | ENSRNOP00000022384 | ENSRNOP00000005671 | Hematopoietically-expressed homeobox. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Plays a central role in controlling thyroid cell metabolism. | 0.478 |
Irf6 | Foxe1 | ENSRNOP00000007333 | ENSRNOP00000012637 | Interferon regulatory factor 6 (Predicted). | Forkhead box E1 (Thyroid transcription factor 2). | 0.605 |
Iyd | Foxe1 | ENSRNOP00000021893 | ENSRNOP00000012637 | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. | Forkhead box E1 (Thyroid transcription factor 2). | 0.608 |
Iyd | Nkx2-1 | ENSRNOP00000021893 | ENSRNOP00000011453 | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circad [...] | 0.458 |