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Kcnh5 protein (Rattus norvegicus) - STRING interaction network
"Kcnh5" - Potassium voltage-gated channel subfamily H member 5 in Rattus norvegicus
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Predicted Interactions
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Kcnh5Potassium voltage-gated channel subfamily H member 5 ; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly (988 aa)    
Predicted Functional Partners:
Kcnab1
Voltage-gated potassium channel subunit beta-1 ; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (Probable). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N- terminal domain and increases the speed of channel closure for other family members (PubMed-8183366, PubM [...] (401 aa)
     
  0.929
Kcnab2
Voltage-gated potassium channel subunit beta-2 ; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed-9763623, PubMed-21357749). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed-10896669, PubMed-16770729, PubMed-18003609, PubMed-21357749). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the cha [...] (367 aa)
     
  0.923
Kcnab3
Voltage-gated potassium channel subunit beta-3 ; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.4 but not Kv1.1 or Kv1.5 (404 aa)
     
  0.923
Kcnd3
Potassium voltage-gated channel subfamily D member 3 ; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (655 aa)
     
 
  0.603
Kcnq2
Potassium voltage-gated channel subfamily KQT member 2 ; Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2 current is blocked by barium and tetraethylammonium whereas 4-aminopyridine and charybdotoxin have no effect on KCNQ2 current. [...] (888 aa)
     
 
  0.518
Kcnq3
Potassium voltage-gated channel subfamily KQT member 3 ; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (873 aa)
     
 
  0.516
Camk2g
Calcium/calmodulin-dependent protein kinase type II subunit gamma ; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-c [...] (506 aa)
     
 
  0.515
Camk2d
Calcium/calmodulin-dependent protein kinase type II subunit delta ; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopat [...] (533 aa)
     
 
  0.515
Camk2b
Calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 (589 aa)
     
 
  0.515
Kcnb1
Potassium voltage-gated channel subfamily B member 1 ; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed-10024359, PubMed-10618149, PubMed-12451110, PubMed-17379638, PubMed-19276663, PubMed-23878 [...] (857 aa)
     
 
  0.489
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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