node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Braf | Dusp6 | ENSRNOP00000014604 | ENSRNOP00000032969 | B-Raf proto-oncogene, serine/threonine kinase. | Dual specificity protein phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family. Implicated in muscle and neuronal differentiation. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). [...] | 0.516 |
Braf | Egfr | ENSRNOP00000014604 | ENSRNOP00000006087 | B-Raf proto-oncogene, serine/threonine kinase. | Receptor protein-tyrosine kinase. | 0.570 |
Braf | Grb2 | ENSRNOP00000014604 | ENSRNOP00000005347 | B-Raf proto-oncogene, serine/threonine kinase. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.636 |
Braf | LOC100910178 | ENSRNOP00000014604 | ENSRNOP00000075379 | B-Raf proto-oncogene, serine/threonine kinase. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | 0.657 |
Braf | Ptpn11 | ENSRNOP00000014604 | ENSRNOP00000041842 | B-Raf proto-oncogene, serine/threonine kinase. | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.676 |
Braf | Spry2 | ENSRNOP00000014604 | ENSRNOP00000013342 | B-Raf proto-oncogene, serine/threonine kinase. | Sprouty RTK-signaling antagonist 2. | 0.955 |
Cbl | Cblb | ENSRNOP00000063226 | ENSRNOP00000074638 | Cbl proto-oncogene. | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | 0.923 |
Cbl | Egfr | ENSRNOP00000063226 | ENSRNOP00000006087 | Cbl proto-oncogene. | Receptor protein-tyrosine kinase. | 0.999 |
Cbl | Frs2 | ENSRNOP00000063226 | ENSRNOP00000071244 | Cbl proto-oncogene. | Fibroblast growth factor receptor substrate 2. | 0.820 |
Cbl | Grb2 | ENSRNOP00000063226 | ENSRNOP00000005347 | Cbl proto-oncogene. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.999 |
Cbl | Hbegf | ENSRNOP00000063226 | ENSRNOP00000025157 | Cbl proto-oncogene. | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). | 0.573 |
Cbl | LOC100910178 | ENSRNOP00000063226 | ENSRNOP00000075379 | Cbl proto-oncogene. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | 0.784 |
Cbl | Ptpn11 | ENSRNOP00000063226 | ENSRNOP00000041842 | Cbl proto-oncogene. | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.916 |
Cbl | Spry2 | ENSRNOP00000063226 | ENSRNOP00000013342 | Cbl proto-oncogene. | Sprouty RTK-signaling antagonist 2. | 0.999 |
Cblb | Cbl | ENSRNOP00000074638 | ENSRNOP00000063226 | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | Cbl proto-oncogene. | 0.923 |
Cblb | Egfr | ENSRNOP00000074638 | ENSRNOP00000006087 | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | Receptor protein-tyrosine kinase. | 0.976 |
Cblb | Grb2 | ENSRNOP00000074638 | ENSRNOP00000005347 | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.861 |
Cblb | Ptpn11 | ENSRNOP00000074638 | ENSRNOP00000041842 | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.431 |
Cblb | Spry2 | ENSRNOP00000074638 | ENSRNOP00000013342 | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | Sprouty RTK-signaling antagonist 2. | 0.792 |
Dusp6 | Braf | ENSRNOP00000032969 | ENSRNOP00000014604 | Dual specificity protein phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family. Implicated in muscle and neuronal differentiation. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). [...] | B-Raf proto-oncogene, serine/threonine kinase. | 0.516 |