node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crls1 | Dolpp1 | ENSRNOP00000028900 | ENSRNOP00000069211 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Dolichyl pyrophosphate phosphatase 1 (Predicted), isoform CRA_b. | 0.457 |
Crls1 | Pgs1 | ENSRNOP00000028900 | ENSRNOP00000004007 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.979 |
Crls1 | Ptpmt1 | ENSRNOP00000028900 | ENSRNOP00000013584 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. [...] | 0.655 |
Crls1 | Tamm41 | ENSRNOP00000028900 | ENSRNOP00000010397 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. | 0.773 |
Crls1 | Taz | ENSRNOP00000028900 | ENSRNOP00000071612 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. | 0.981 |
Dnajc19 | Ptpmt1 | ENSRNOP00000065070 | ENSRNOP00000013584 | Similar to homolog of yeast TIM14 isoform c (Predicted), isoform CRA_a. | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. [...] | 0.533 |
Dnajc19 | Taz | ENSRNOP00000065070 | ENSRNOP00000071612 | Similar to homolog of yeast TIM14 isoform c (Predicted), isoform CRA_a. | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. | 0.746 |
Dolpp1 | Crls1 | ENSRNOP00000069211 | ENSRNOP00000028900 | Dolichyl pyrophosphate phosphatase 1 (Predicted), isoform CRA_b. | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.457 |
Dolpp1 | Ptpmt1 | ENSRNOP00000069211 | ENSRNOP00000013584 | Dolichyl pyrophosphate phosphatase 1 (Predicted), isoform CRA_b. | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. [...] | 0.608 |
Kbtbd4 | Mtch2 | ENSRNOP00000071649 | ENSRNOP00000072917 | Kelch repeat and BTB (POZ) domain containing 4 (Predicted), isoform CRA_c. | Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.702 |
Kbtbd4 | Ndufaf3 | ENSRNOP00000071649 | ENSRNOP00000027262 | Kelch repeat and BTB (POZ) domain containing 4 (Predicted), isoform CRA_c. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). | 0.464 |
Kbtbd4 | Ndufs3 | ENSRNOP00000071649 | ENSRNOP00000012425 | Kelch repeat and BTB (POZ) domain containing 4 (Predicted), isoform CRA_c. | NADH dehydrogenase (Ubiquinone) Fe-S protein 3 (Predicted), isoform CRA_c; Belongs to the complex I 30 kDa subunit family. | 0.640 |
Kbtbd4 | Ptpmt1 | ENSRNOP00000071649 | ENSRNOP00000013584 | Kelch repeat and BTB (POZ) domain containing 4 (Predicted), isoform CRA_c. | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. [...] | 0.653 |
Mtch2 | Kbtbd4 | ENSRNOP00000072917 | ENSRNOP00000071649 | Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Kelch repeat and BTB (POZ) domain containing 4 (Predicted), isoform CRA_c. | 0.702 |
Mtch2 | Ndufaf3 | ENSRNOP00000072917 | ENSRNOP00000027262 | Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). | 0.443 |
Mtch2 | Ndufs3 | ENSRNOP00000072917 | ENSRNOP00000012425 | Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | NADH dehydrogenase (Ubiquinone) Fe-S protein 3 (Predicted), isoform CRA_c; Belongs to the complex I 30 kDa subunit family. | 0.731 |
Mtch2 | Ptpmt1 | ENSRNOP00000072917 | ENSRNOP00000013584 | Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. [...] | 0.650 |
Ndufaf3 | Kbtbd4 | ENSRNOP00000027262 | ENSRNOP00000071649 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). | Kelch repeat and BTB (POZ) domain containing 4 (Predicted), isoform CRA_c. | 0.464 |
Ndufaf3 | Mtch2 | ENSRNOP00000027262 | ENSRNOP00000072917 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). | Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.443 |
Ndufaf3 | Ndufs3 | ENSRNOP00000027262 | ENSRNOP00000012425 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). | NADH dehydrogenase (Ubiquinone) Fe-S protein 3 (Predicted), isoform CRA_c; Belongs to the complex I 30 kDa subunit family. | 0.994 |