STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sem1SEM1, 26S proteasome complex subunit. (70 aa)    
Predicted Functional Partners:
Brca2
Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]
    
 0.999
Psmd3
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3, isoform CRA_b.
   
 0.997
Psmd14
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14.
   
 0.997
Psmd6
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6, isoform CRA_a.
   
 0.995
Pcid2
PCI domain-containing 2.
   
 
 0.989
Psmd12
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12.
   
 0.987
Psmd7
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Predicted).
   
 0.987
Psmd8
Proteasome 26S subunit, non-ATPase 8.
   
 0.987
Psmd4
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_a.
   
 0.987
Psmc6
Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.
   
 0.986
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.