STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fam126aFamily with sequence similarity 126, member A. (521 aa)    
Predicted Functional Partners:
Ttc7b
Tetratricopeptide repeat domain 7B.
    
 
 0.965
Pi4ka
Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate.
    
 
 0.919
Ttc7a
Tetratricopeptide repeat domain 7A.
    
 
 0.887
Efr3b
EFR3 homolog B.
      
 0.673
Il1rapl2
Interleukin 1 receptor accessory protein-like 2.
      
 0.643
Aimp1
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1.
      
 0.610
Gjc2
Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity); Belongs to the connexin family. Gamma-type subfamily.
      
 0.607
Lypd6
Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Enhances nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
      
 0.579
Efr3a
Similar to RIKEN cDNA C920006C10 (Predicted).
      
 0.560
Rxfp3
Relaxin-3/INSL7 receptor 1 long form.
    
 
 0.542
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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