STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HeltHelt bHLH transcription factor. (240 aa)    
Predicted Functional Partners:
Ascl1
Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG- 3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in mo [...]
   
 
 0.679
Slc6a7
Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals.
      
 0.651
Wdr83os
Similar to cDNA sequence BC056474 (Predicted), isoform CRA_b.
      
 0.638
Tal2
TAL bHLH transcription factor 2.
   
 
 0.635
Hes3
Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription.
      
 0.535
Znrd1as
Zinc ribbon domain-containing 1 antisense.
      
 0.528
Rbpjl2
Recombination signal-binding protein for immunoglobulin kappa J region-like 2.
    
 
 0.489
Rexo4
REX4, RNA exonuclease 4 homolog (S. cerevisiae).
      
 0.470
Fancg
FA complementation group G.
    
 
 0.463
Mybphl
Myosin-binding protein H-like; Belongs to the immunoglobulin superfamily. MyBP family.
      
 0.438
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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