node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cul1 | Fbxl15 | ENSRNOP00000007620 | ENSRNOP00000026471 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. | 0.924 |
Cul1 | Fbxl2 | ENSRNOP00000007620 | ENSRNOP00000033447 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box and leucine-rich repeat protein 2. | 0.673 |
Cul1 | Fbxl20 | ENSRNOP00000007620 | ENSRNOP00000060552 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | 0.696 |
Cul1 | Fbxo3 | ENSRNOP00000007620 | ENSRNOP00000014478 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | 0.884 |
Cul1 | Rbx1 | ENSRNOP00000007620 | ENSRNOP00000069049 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul1 | Skp1 | ENSRNOP00000007620 | ENSRNOP00000073214 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Dimt1 | Fbxo3 | ENSRNOP00000018527 | ENSRNOP00000014478 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | 0.589 |
Fbxl15 | Cul1 | ENSRNOP00000026471 | ENSRNOP00000007620 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.924 |
Fbxl15 | Fbxo3 | ENSRNOP00000026471 | ENSRNOP00000014478 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | 0.581 |
Fbxl15 | Rbx1 | ENSRNOP00000026471 | ENSRNOP00000069049 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. | Ring-box 1. | 0.682 |
Fbxl15 | Skp1 | ENSRNOP00000026471 | ENSRNOP00000073214 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.987 |
Fbxl2 | Cul1 | ENSRNOP00000033447 | ENSRNOP00000007620 | F-box and leucine-rich repeat protein 2. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.673 |
Fbxl2 | Fbxo3 | ENSRNOP00000033447 | ENSRNOP00000014478 | F-box and leucine-rich repeat protein 2. | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | 0.751 |
Fbxl2 | Skp1 | ENSRNOP00000033447 | ENSRNOP00000073214 | F-box and leucine-rich repeat protein 2. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.872 |
Fbxl20 | Cul1 | ENSRNOP00000060552 | ENSRNOP00000007620 | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.696 |
Fbxl20 | Fbxo3 | ENSRNOP00000060552 | ENSRNOP00000014478 | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | 0.705 |
Fbxl20 | Skp1 | ENSRNOP00000060552 | ENSRNOP00000073214 | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.877 |
Fbxo3 | Cul1 | ENSRNOP00000014478 | ENSRNOP00000007620 | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.884 |
Fbxo3 | Dimt1 | ENSRNOP00000014478 | ENSRNOP00000018527 | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.589 |
Fbxo3 | Fbxl15 | ENSRNOP00000014478 | ENSRNOP00000026471 | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance; Belongs to the FBXL15 family. | 0.581 |