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Celf1 protein (Rattus norvegicus) - STRING interaction network
"Celf1" - CUGBP Elav-like family member 1 in Rattus norvegicus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Celf1CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons- promotes inclusion of the smooth muscle (SM) exon bu [...] (487 aa)    
Predicted Functional Partners:
Mbnl1
Muscleblind-like splicing regulator 1 (387 aa)
     
 
  0.869
Mbnl2
Muscleblind-like protein 2; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5’ACACCC-3’ core sequence, termed zipcode, within the 3’UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expr [...] (372 aa)
     
 
  0.842
Cebpd
CCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity); Belongs to the bZIP family. C/EBP subfamily (268 aa)
     
   
  0.806
Mbnl3
Muscleblind-like splicing regulator 3 (343 aa)
     
 
  0.797
Khsrp
Far upstream element-binding protein 2; Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity). Binds to the dendritic targeting element and may play a [...] (721 aa)
     
 
  0.753
Dmpk
Dystrophia myotonica-protein kinase (631 aa)
       
 
  0.744
Zcwpw1
Zinc finger, CW-type with PWWP domain 1 (637 aa)
           
  0.727
ENSRNOG00000024425
Zinc finger CW-type PWWP domain protein 1-like (620 aa)
           
  0.727
Nme8
Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity); In the C-terminal section; belongs to the NDK family (596 aa)
     
   
  0.713
Raly
RNA binding protein, autoantigenic (HnRNP-associated with lethal yellow homolog (Mouse)); RALY heterogeneous nuclear ribonucleoprotein (285 aa)
     
 
  0.709
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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