node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ism2 | Kdsr | ENSRNOP00000067510 | ENSRNOP00000003728 | Isthmin 2. | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.672 |
Ism2 | Ormdl1 | ENSRNOP00000067510 | ENSRNOP00000061507 | Isthmin 2. | ORMDL sphingolipid biosynthesis regulator 1. | 0.589 |
Ism2 | Ormdl2 | ENSRNOP00000067510 | ENSRNOP00000047680 | Isthmin 2. | ORM1-like protein; Negative regulator of sphingolipid synthesis. | 0.589 |
Ism2 | Ormdl3 | ENSRNOP00000067510 | ENSRNOP00000046432 | Isthmin 2. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.589 |
Ism2 | Sptlc1 | ENSRNOP00000067510 | ENSRNOP00000014546 | Isthmin 2. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.907 |
Ism2 | Sptssa | ENSRNOP00000067510 | ENSRNOP00000005825 | Isthmin 2. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.458 |
Kdsr | Ism2 | ENSRNOP00000003728 | ENSRNOP00000067510 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Isthmin 2. | 0.672 |
Kdsr | Smpd2 | ENSRNOP00000003728 | ENSRNOP00000000336 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso- sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero- 3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. | 0.516 |
Kdsr | Sptlc1 | ENSRNOP00000003728 | ENSRNOP00000014546 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.996 |
Kdsr | Sptlc2 | ENSRNOP00000003728 | ENSRNOP00000016324 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). | 0.990 |
Kdsr | Sptlc3 | ENSRNOP00000003728 | ENSRNOP00000005920 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase, long chain base subunit 3. | 0.990 |
Kdsr | Sptssa | ENSRNOP00000003728 | ENSRNOP00000005825 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.637 |
Kdsr | Ugcg | ENSRNOP00000003728 | ENSRNOP00000021110 | Follicular lymphoma variant translocation 1 (Predicted), isoform CRA_a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ceramide glucosyltransferase; Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that m [...] | 0.655 |
Ormdl1 | Ism2 | ENSRNOP00000061507 | ENSRNOP00000067510 | ORMDL sphingolipid biosynthesis regulator 1. | Isthmin 2. | 0.589 |
Ormdl1 | Ormdl2 | ENSRNOP00000061507 | ENSRNOP00000047680 | ORMDL sphingolipid biosynthesis regulator 1. | ORM1-like protein; Negative regulator of sphingolipid synthesis. | 0.621 |
Ormdl1 | Ormdl3 | ENSRNOP00000061507 | ENSRNOP00000046432 | ORMDL sphingolipid biosynthesis regulator 1. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.591 |
Ormdl1 | Sptlc1 | ENSRNOP00000061507 | ENSRNOP00000014546 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.953 |
Ormdl1 | Sptlc2 | ENSRNOP00000061507 | ENSRNOP00000016324 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). | 0.884 |
Ormdl1 | Sptlc3 | ENSRNOP00000061507 | ENSRNOP00000005920 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase, long chain base subunit 3. | 0.884 |
Ormdl1 | Sptssa | ENSRNOP00000061507 | ENSRNOP00000005825 | ORMDL sphingolipid biosynthesis regulator 1. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.913 |